Christopher K Cowan

US Patent:

20220340617, Oct 27, 2022

Filed:

May 11, 2022

Appl. No.:

17/742243

Inventors:

- Tarrytown NY, US
Christopher Cowan - Tarrytown NY, US
Andrew Tustian - Tarrytown NY, US

International Classification:

C07K 1/36
C07K 1/14
C07K 1/34
G01N 1/40
G01N 21/65

Abstract:

In situ Raman spectroscopy methods and systems for characterizing or quantifying a protein purification intermediate and/or final concentrated pool during production or manufacture are provided. In one embodiment, in situ Raman spectroscopy is used to characterize or quantify protein purification intermediates critical quality attributes during downstream processing (i.e., after harvest of the protein purification intermediate). For example, the disclosed in situ Raman spectroscopy methods and systems can be used to characterize and quantify protein purification intermediates as the protein purification intermediates are purified, condensed, or otherwise formulated into the final drug product to be sold or administered.

US Patent:

20200062802, Feb 27, 2020

Filed:

Aug 26, 2019

Appl. No.:

16/550989

Inventors:

- Tarrytown NY, US
Christopher Cowan - Tarrytown NY, US
Andrew Tustian - Tarrytown NY, US

International Classification:

C07K 1/36
G01N 1/40
C07K 1/34
C07K 1/14
G01N 21/65

Abstract:

In situ Raman spectroscopy methods and systems for characterizing or quantifying a protein purification intermediate and/or final concentrated pool during production or manufacture are provided. In one embodiment, in situ Raman spectroscopy is used to characterize or quantify protein purification intermediates critical quality attributes during downstream processing (i.e., after harvest of the protein purification intermediate). For example, the disclosed in situ Raman spectroscopy methods and systems can be used to characterize and quantify protein purification intermediates as the protein purification intermediates are purified, condensed, or otherwise formulated into the final drug product to be sold or administered