Christopher E Dube

US Patent:

6933409, Aug 23, 2005

Filed:

May 15, 2000

Appl. No.:

09/571567

Inventors:

Damodara M. Poojary - Cupertino CA, US
Ramesh Borade - San Jose CA, US
Alfred Hagemeyer - Sunnyvale CA, US
Xiao Ping Zhou - Sunnyvale CA, US
Christopher E. Dube - Arlington MA, US
Ulrich Notheis - Dormagen, DE
Ralph Armbrust - Leverkusen, DE
Christian Rasp - Bergisch Gladbach, DE
David M. Lowe - Mountain View CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA
Bayer AG - Leverkusen

International Classification:

C07C209/00

US Classification:

564408, 564395

Abstract:

Noble metal/reducible metal oxide catalysts effective for the direct amination of aromatic hydrocarbons and heterocyclic analogs thereof are disclosed. In one embodiment, the cataloxidant comprises a noble metal selected from Pd, Rh, Ir and/or Ru and a reducible metal oxide. In another embodiment, the cataloxidant comprises a noble metal and a reducible oxide of a metal selected from Ni, Mn, V, Ce, Th, Pr, Te, Re, Co, Fe, Cu and/or Bi. A preferred cataloxidant comprises one or more noble metals selected from Pd, Rh, Ir and/or Ru, in combination with nickel oxide and/or manganese oxide. In preferred applications, benzene can be aminated in the presence of the cataloxidants to form aniline. A benzene conversion of at least 5% is achieved, with more than 90% selectivity for aniline. Significantly, the cataloxidant can be regenerated without a substantial loss of performance.

US Patent:

7115231, Oct 3, 2006

Filed:

Oct 17, 2000

Appl. No.:

09/691421

Inventors:

Xiao Ping Zhou - Lompoc CA, US
Sam Bergh - San Francisco CA, US
Christopher E. Dube - Lexington MA, US
Lynn Van Erden - Livermore CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01L 3/00

US Classification:

422102

Abstract:

An apparatus for use in parallel reaction of materials. The apparatus includes a base having a plurality of reaction wells formed therein and a sealing device positioned over the reaction wells for individually sealing each of the reaction wells. One of the sealing device and the base having chamfered ridges extending generally around a periphery of each of said plurality of reaction wells. The other of the sealing device and the base having a contact surface formed of a material softer than the material of the chamfered ridges to create a knife-edge seal between the sealing device and the base when the sealing device and the base are forced into contact with one another.

US Patent:

20020187559, Dec 12, 2002

Filed:

Jun 14, 2002

Appl. No.:

10/172607

Inventors:

Peter Desrosiers - Cupertino CA, US
Christopher Dube - San Jose CA, US
Xiao Zhou - Sunnyvale CA, US

Assignee:

Symyx Technologies, Inc.

International Classification:

G01N031/10

US Classification:

436/167000, 436/164000, 436/171000, 436/173000, 436/178000, 436/181000, 436/037000, 422/068100, 422/082050, 422/082080, 422/083000, 422/088000

Abstract:

Methods and devices for rapidly analyzing groups of reactions are disclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.

US Patent:

20030069560, Apr 10, 2003

Filed:

May 2, 2002

Appl. No.:

10/139656

Inventors:

Anthony Adamis - Jamaica Plain MA, US
Joan Miller - Winchester MA, US
Evangelos Gragoudas - Lexington MA, US
Mark Mescher - West Newton MA, US
Christopher Dube - Lexington MA, US
Jeffrey Borenstein - Holliston MA, US
Marcie Weinstein - Pittsburgh PA, US
Raanan Miller - Chestnut Hill MA, US
Mitchell Hansberry - Southborough MA, US

Assignee:

Massachusetts Eye and Ear Infirmary - Boston MA

International Classification:

A61M031/00

US Classification:

604/521000, 604/890100

Abstract:

The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.

US Patent:

20030151400, Aug 14, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/075754

Inventors:

Anthony Petrovich - Tewksbury MA, US
John Williams - Lexington MA, US
Christopher Dube - Lexington MA, US

International Classification:

G01R023/00

US Classification:

324/076520

Abstract:

A sensor readout circuit which provides a frequency signal output including a phase detector circuit responsive to an output signal from a sensor and an input signal to the sensor and configured to detect the phase difference between the input signal and the output signal, and a drive circuit responsive to the phase detector circuit and configured to maintain a fixed phase difference between the input signal and the output signal.

US Patent:

20040089357, May 13, 2004

Filed:

Jun 23, 2003

Appl. No.:

10/601606

Inventors:

Christopher Dube - Lexington MA, US
Jason Fiering - Cambridge MA, US
Mark Mescher - West Newton MA, US

International Classification:

F16K027/00

US Classification:

137/884000

Abstract:

An integrated electrofluidic system including an electronic control system amounted on a support platform, a microfluidic system embedded in the platform and having an input and an output and at least one electrofluidic component, and at least one electrical conductor carried by the platform for electrically interconnecting the electronic control system and the at least one electrofluidic component.

US Patent:

20050196877, Sep 8, 2005

Filed:

Mar 2, 2004

Appl. No.:

10/791108

Inventors:

Marc Weinberg - Needham MA, US
Jeffrey Borenstein - Holliston MA, US
Christopher Dube - Lexington MA, US
Ralph Hopkins - Chestnut Hill MA, US
Edwin Carlen - Cambridge MA, US

Assignee:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

G01N033/543

US Classification:

436518000, 422082010

Abstract:

Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses cause diaphragm displacements that are sensed as varying capacitance.

US Patent:

20050238506, Oct 27, 2005

Filed:

Jun 28, 2005

Appl. No.:

11/169211

Inventors:

Mark Mescher - West Newton MA, US
Jason Fiering - Cambridge MA, US
Christopher Dube - Lexington MA, US

Assignee:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

F04B017/00
F04B035/04

US Classification:

417413100, 417050000, 417410100, 417413300

Abstract:

A variable, closed-loop apparatus for regulating a microfluidic flow that employs a low-power deflection assembly, which is surface-mounted over a flexible membrane overlying a chamber integrated into a microfabricated platform. A flexible membrane, moveable between two positions, sealingly overlies the chamber. One of the positions of the membrane restricts the flow through the chamber to a greater degree than the other position. A deflection assembly disposed on the substrate over the membrane unidirectionally deflects the membrane, thereby regulating the flow through the chamber.