Christopher G Fraser

US Patent:

6630575, Oct 7, 2003

Filed:

Jul 20, 2001

Appl. No.:

09/910174

Inventors:

Anthony J. Coyle - Boston MA
Christopher C. Fraser - Lexington MA
Stephen Manning - Arlington MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 14705

US Classification:

530350, 530395, 5303873

Abstract:

B7-Like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

6635750, Oct 21, 2003

Filed:

Jul 20, 2000

Appl. No.:

09/620461

Inventors:

Anthony J. Coyle - Boston MA
Christopher C. Fraser - Lexington MA
Stephen Manning - Arlington MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07H 2104

US Classification:

536 235, 536 231, 536 234, 435 691, 435 697, 435455, 435471, 4352523, 4353201, 435810

Abstract:

B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

6960651, Nov 1, 2005

Filed:

Jul 2, 2002

Appl. No.:

10/188495

Inventors:

Susan J. Kirst - Brookline MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Christopher C. Fraser - Lexington MA, US
John D. Sharp - Arlington MA, US
Thomas S. Barnes - Boston MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K038/00
A61K039/00

US Classification:

530350, 530300, 514 2, 514 8, 4242781, 4241921, 435 697, 435440, 536 231

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

7033780, Apr 25, 2006

Filed:

Jun 14, 1999

Appl. No.:

09/333159

Inventors:

Sean A. McCarthy - Boston MA, US
Christopher C. Fraser - Lexington MA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Boston MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 15/00

US Classification:

435 691, 4353201, 4352523, 435325, 435 6, 536 232, 536 235, 530350

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

7083793, Aug 1, 2006

Filed:

Mar 26, 2002

Appl. No.:

10/107857

Inventors:

Christopher C. Fraser - Lexington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 39/00
C07K 19/00
C07K 14/435

US Classification:

4241921, 530350, 536 232, 536 234

Abstract:

The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also described/disclosed.

US Patent:

7109319, Sep 19, 2006

Filed:

Mar 10, 2003

Appl. No.:

10/384850

Inventors:

Christopher C. Fraser - Lexington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 15/12
C12N 15/63
C12P 21/00

US Classification:

536 235, 435 691, 4353201, 4352523, 4352542

Abstract:

The invention provides isolated nucleic acid molecules, designated FAIL, which encode polypeptide molecules containing Ig and Ig-like domains and which are homologous to FcγRI. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7160694, Jan 9, 2007

Filed:

Jan 19, 2001

Appl. No.:

09/766511

Inventors:

Christopher C. Fraser - Lexington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12P 21/06

US Classification:

435 691, 4352523, 4353201, 435325, 435 6, 536 235

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

7282209, Oct 16, 2007

Filed:

Aug 27, 2004

Appl. No.:

10/929150

Inventors:

Christopher C. Fraser - Lexington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 39/00
C07K 14/47

US Classification:

4241851, 4241921, 530350, 536 235, 536 234, 514 12

Abstract:

The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.