Christopher D Fraser

US Patent:

20020182675, Dec 5, 2002

Filed:

Oct 25, 2001

Appl. No.:

10/042431

Inventors:

Sean McCarthy - San Diego CA, US
Christopher Fraser - Lexington MA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12P021/02
C12N005/06
C07K014/435
C07H021/04
C12N009/00

US Classification:

435/069100, 435/183000, 435/320100, 435/325000, 530/350000, 536/023200

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20090136959, May 28, 2009

Filed:

Oct 23, 2008

Appl. No.:

12/288775

Inventors:

Sean A. McCarthy - San Diego CA, US
Christopher C. Fraser - Lexington MA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Brookline MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Jamaica Plain MA, US
Nicholas Wrighton - Winchester MA, US
Andrew D.J. Goodearl - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Mehran Khodadoust - Brookline MA, US

International Classification:

C12Q 1/68
C12N 15/11
C12N 15/00
C12N 5/06
C07K 14/00
G01N 33/00
C07K 1/00
C07K 16/18
C12P 21/04
G01N 33/53

US Classification:

435 6, 536 231, 4353201, 435325, 530350, 5303879, 435 691, 435 72, 435375, 435402, 436 86

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.