Christopher Paul Hanna

US Patent:

8057668, Nov 15, 2011

Filed:

Oct 28, 2010

Appl. No.:

12/914874

Inventors:

Douglas T. Gjerde - Saratoga CA, US
Christopher P. Hanna - Elmhurst IL, US

Assignee:

PhyNexus, Inc. - San Jose CA

International Classification:

B01J 20/291
B01D 15/08
B01J 20/00

US Classification:

2101982, 210656, 422501

Abstract:

The invention provides extraction columns for the purification of an analyte (e. g. , a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides columns characterized by low backpressure.

US Patent:

8284954, Oct 9, 2012

Filed:

Oct 30, 2007

Appl. No.:

11/927751

Inventors:

Christopher M. Hanna - Marlborough MA, US

Assignee:

THAT Corporation - Milford MA

International Classification:

H04R 1/40
H03G 7/00

US Classification:

381 97, 381106

Abstract:

The disclosed BTSC encoder includes a left high pass filter means for receiving a digital left channel audio signal and for digitally high pass filtering the digital left channel audio signal and thereby generating a digital left filtered signal; a right high pass filter means for receiving a digital right channel audio signal and for digitally high pass filtering the digital right channel audio signal and thereby generating a digital right filtered signal; a matrix means for receiving the digital left and digital right filtered signals, and including means for summing the digital left and digital right filtered signals and thereby generating a digital sum signal, and including means for subtracting one of the digital left and digital right filtered signals from the other of the digital left and digital right filtered signals and thereby generating a digital difference signal; a difference channel processing means for digitally processing the digital difference signal; and a sum channel processing means for digitally processing the digital sum signal.

US Patent:

8315411, Nov 20, 2012

Filed:

Nov 16, 2009

Appl. No.:

12/619655

Inventors:

Christopher M. Hanna - Arlington MA, US
Gregory Benulis - Boxford MA, US

Assignee:

THAT Corporation - Milford MA

International Classification:

H03G 3/00
H03G 7/00
H04B 15/00

US Classification:

381107, 381108, 381106, 381 945

Abstract:

A disclosed system and method dynamically controls the perceived volume of a stereo audio program including left and right channel signals. The system comprises: a dynamic volume control configured and arranged so as to maintain a perceived constant volume level of the stereo audio program; and an excessive spatial processing protection processor configured and arranged for controlling the level of a difference signal, created as a function of the right channel signal subtracted from the left channel signal (L−R), relative to the level of a sum signal, created as a function of the right channel signal plus the left channel signal; wherein the excessive spatial processing protection processor processes the audio signals so as to control the difference (L−R) signal relative to the sum (L+R) signal. A system and method are also provided for dynamically controlling the perceived volume of a stereo audio program including left and right channel signals, comprising: a dynamic volume control configured and arranged so as to maintain a perceived constant volume level of the stereo audio program; and a program change detector configured and arranged to provide a program change signal indicating that the volume of the left and right channel signals has dropped below a threshold level for at least a threshold time period so as to anticipate a possible change in the sound level of the left and right channel signals; wherein the dynamic volume control is responsive to the program change signal.

US Patent:

8362219, Jan 29, 2013

Filed:

Jan 11, 2010

Appl. No.:

12/685485

Inventors:

Douglas T. Gjerde - Saratoga CA, US
Christopher P. Hanna - Elmhurst IL, US

Assignee:

PhyNexus, Inc. - San Jose CA

International Classification:

C07K 1/22
B01D 15/00
G01N 30/02

US Classification:

530412, 210656, 422 70, 530415

Abstract:

The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; purging bulk liquid from said extraction channel; and eluting the analyte by passing a desorption solvent through the channel. In some embodiments, the analyte is a protein. The invention further provides reagents, channels, columns and instrumentation related to this and other methods.

US Patent:

8501116, Aug 6, 2013

Filed:

Aug 9, 2011

Appl. No.:

13/206435

Inventors:

Douglas T. Gjerde - Saratoga CA, US
Christopher P. Hanna - Elmhurst IL, US

Assignee:

PhyNexus, Inc. - San Jose CA

International Classification:

B01L 3/00

US Classification:

422501

Abstract:

The invention provides extraction columns for the purification of an analyte (e. g. , a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The invention is characterized by the use of low dead volume columns, which is achieved in part by the use of low pore volume frits (e. g. , membrane screens) to contain a bed of extraction media in the column. Low dead volume facilitates the elution of the captured analyte into a very small volume of desorption solution, allowing for the preparation of low volume samples containing relatively high concentrations of analyte.

US Patent:

20060202922, Sep 14, 2006

Filed:

Mar 9, 2006

Appl. No.:

11/373535

Inventors:

Christopher Hanna - Park Ridge IL, US
Douglas Gjerde - Saratoga CA, US

International Classification:

G09G 3/30

US Classification:

345076000

Abstract:

This invention relates to a method of optimizing a process for extracting an analyte from a liquid sample. A plurality of samples can be processed simultaneously while varying several factors independently to determine extraction efficiency under a wide variety of conditions.

US Patent:

20070016316, Jan 18, 2007

Filed:

Jun 2, 2006

Appl. No.:

11/445670

Inventors:

Christopher Hanna - Arlington MA, US

International Classification:

G06F 17/00

US Classification:

700094000

Abstract:

The disclosed BTSC encoder includes a left high pass filter means for receiving a digital left channel audio signal and for digitally high pass filtering the digital left channel audio signal and thereby generating a digital left filtered signal; a right high pass filter means for receiving a digital right channel audio signal and for digitally high pass filtering the digital right channel audio signal and thereby generating a digital right filtered signal; a matrix means for receiving the digital left and digital right filtered signals, and including means for summing the digital left and digital right filtered signals and thereby generating a digital sum signal, and including means for subtracting one of the digital left and digital right filtered signals from the other of the digital left and digital right filtered signals and thereby generating a digital difference signal; a difference channel processing means for digitally processing the digital difference signal; and a sum channel processing means for digitally processing the digital sum signal.

US Patent:

20080095376, Apr 24, 2008

Filed:

Oct 30, 2007

Appl. No.:

11/927739

Inventors:

Christopher Hanna - Marlborough MA, US

Assignee:

THAT Corporation - Milford MA

International Classification:

H04H 20/88

US Classification:

381002000

Abstract:

The disclosed BTSC encoder includes a left high pass filter means for receiving a digital left channel audio signal and for digitally high pass filtering the digital left channel audio signal and thereby generating a digital left filtered signal; a right high pass filter means for receiving a digital right channel audio signal and for digitally high pass filtering the digital right channel audio signal and thereby generating a digital right filtered signal; a matrix means for receiving the digital left and digital right filtered signals, and including means for summing the digital left and digital right filtered signals and thereby generating a digital sum signal, and including means for subtracting one of the digital left and digital right filtered signals from the other of the digital left and digital right filtered signals and thereby generating a digital difference signal; a difference channel processing means for digitally processing the digital difference signal; and a sum channel processing means for digitally processing the digital sum signal.