Christopher A Lambert

US Patent:

7935309, May 3, 2011

Filed:

Apr 14, 2006

Appl. No.:

11/404319

Inventors:

W. Grant McGimpsey - Boylston MA, US
Christopher R. Lambert - Hudson MA, US
John S. Benco - Holliston MA, US
Venkat R. Thalladi - Worcester MA, US

Assignee:

Worcester Polytechnic Institute - Worcester MA

International Classification:

G01N 21/62
G01N 21/64
G01N 27/00
G01N 33/00
G01N 33/20
G01N 33/48
G01N 33/50
G01N 33/53
G01N 33/533

US Classification:

422 8208, 422 50, 422 681, 422 8201, 422 8202, 422 8203, 422 8206, 422102, 422103, 422104, 4352872, 436 73, 507136

Abstract:

In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of analyte detection, utilize two transduction mechanisms from the same molecule to determine analyte presence, analyte concentration, or both. An analyte sensing molecule is used that can provide both an optical signal and electrochemical signal when an analyte is recognized by an analyte binding portion of the sensing molecule.

US Patent:

8008088, Aug 30, 2011

Filed:

Jun 26, 2006

Appl. No.:

11/475784

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

G01N 33/00
A61K 49/00

US Classification:

436 95, 436172, 436164, 436518, 436546, 424 96, 424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8029765, Oct 4, 2011

Filed:

Dec 23, 2004

Appl. No.:

10/584821

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8357662, Jan 22, 2013

Filed:

Sep 10, 2007

Appl. No.:

12/440328

Inventors:

W. Grant McGimpsey - Worcester MA, US
Christopher R. Lambert - Worcester MA, US

Assignee:

Worcester Polytechnic Institute - Worcester MA

International Classification:

A61K 38/12
C07K 7/50
C07K 7/54

US Classification:

514 211, 530318, 540454

Abstract:

A compound sensitive to and selective for ammonium ions over other ions. A sensor fabricated from a self assembled monolayer of said compound on gold, exhibiting sensitivity and selectivity for ammonium ions over other ions in aqueous solutions, including blood. A method of preparation of said compound and said sensor.

US Patent:

8362447, Jan 29, 2013

Filed:

Jul 14, 2008

Appl. No.:

12/668938

Inventors:

Christopher R. Lambert - Worcester MA, US

Assignee:

Worcester Polytechnic Institute - Worcester MA

International Classification:

G01N 21/64

US Classification:

2504591

Abstract:

The present invention is a low-cost, easily deployed, degradable taggant that can be dispersed over a wide area to serve as a witness to activity in the area and for queuing of other sensors. The taggant enables nearly real-time change detection within the treated area using one or more simple optical sensing techniques.

US Patent:

8466286, Jun 18, 2013

Filed:

Aug 22, 2011

Appl. No.:

13/215061

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C07F 5/02
A61K 49/00
A61B 5/00
A61B 8/00
A61B 10/00
C07D 471/00

US Classification:

546 13, 546 66, 514288, 514 64, 436 95, 436172, 436164, 424 91, 424 96

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8509867, Aug 13, 2013

Filed:

Feb 7, 2006

Appl. No.:

11/349731

Inventors:

Jerome J. Workman - Madison WI, US
Christopher R. Lambert - Hudson MA, US
Robert L. Coleman - Olive Hill KY, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

A61B 5/145
A61B 5/1455

US Classification:

600316, 600306, 600310, 600322, 600329, 600365, 600473, 600476, 436 63, 436 95, 436164, 436172

Abstract:

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.

US Patent:

20020133080, Sep 19, 2002

Filed:

Feb 6, 2002

Appl. No.:

10/066778

Inventors:

William Apruzzese - Everett MA, US
Pierre Trepagnier - Medford MA, US
Russell Gray - Brownsburg IN, US
James Mansfield - Boston MA, US
Christopher Lambert - Hudson MA, US

International Classification:

A61B006/00

US Classification:

600/477000

Abstract:

The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device of the invention comprises at least one scattering layer, which is preferably non-fluorescent, and a second layer containing one or more fluorophore. Light passes through the scattering layer and excites the fluorophore. Light emitted from the fluorophore passes back though the scattering layer and into collecting optics, which can be measured and that measurement used to correct for instrument drift.