Christopher R Lambert

US Patent:

8008088, Aug 30, 2011

Filed:

Jun 26, 2006

Appl. No.:

11/475784

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

G01N 33/00
A61K 49/00

US Classification:

436 95, 436172, 436164, 436518, 436546, 424 96, 424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8029765, Oct 4, 2011

Filed:

Dec 23, 2004

Appl. No.:

10/584821

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8466286, Jun 18, 2013

Filed:

Aug 22, 2011

Appl. No.:

13/215061

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C07F 5/02
A61K 49/00
A61B 5/00
A61B 8/00
A61B 10/00
C07D 471/00

US Classification:

546 13, 546 66, 514288, 514 64, 436 95, 436172, 436164, 424 91, 424 96

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

20020133080, Sep 19, 2002

Filed:

Feb 6, 2002

Appl. No.:

10/066778

Inventors:

William Apruzzese - Everett MA, US
Pierre Trepagnier - Medford MA, US
Russell Gray - Brownsburg IN, US
James Mansfield - Boston MA, US
Christopher Lambert - Hudson MA, US

International Classification:

A61B006/00

US Classification:

600/477000

Abstract:

The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device of the invention comprises at least one scattering layer, which is preferably non-fluorescent, and a second layer containing one or more fluorophore. Light passes through the scattering layer and excites the fluorophore. Light emitted from the fluorophore passes back though the scattering layer and into collecting optics, which can be measured and that measurement used to correct for instrument drift.

US Patent:

20040106163, Jun 3, 2004

Filed:

Jul 10, 2003

Appl. No.:

10/617915

Inventors:

Jerome Workman - Brookline MA, US
Christopher Lambert - Hudson MA, US

International Classification:

C12Q001/54

US Classification:

435/014000

Abstract:

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatus, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more analytes or parameters found in skin.