Christopher W Macdonald

US Patent:

20210292817, Sep 23, 2021

Filed:

Jul 10, 2019

Appl. No.:

17/258880

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/6816
G16B 40/00
G01N 21/64
G01N 21/76

Abstract:

The present disclosure provides methods, systems, and compositions of quantifying one or more analytes in a single sample volume without immobilization, separation, mass spectrometry, or melting curve analysis. Methods may comprise polymerase chain reaction and signal generation to quantify the analytes.

US Patent:

20210087607, Mar 25, 2021

Filed:

May 7, 2020

Appl. No.:

16/869481

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/686
C12N 9/22
C12Q 1/6806
C12Q 1/6823

Abstract:

The present disclosure provides methods and compositions for nucleic acid detection. Nucleic acids may be derived from any source including, for example, viruses, bacterial cells, and eukaryotic cells. The methods of the present disclosure may be used to detect the presence of at least one member of a plurality of nucleic acids in a sample. The methods of the present disclosure may be used to detect the presence of both a first and second member of a plurality of nucleic acids in a sample. Nucleic acids may be detected by the generation of one or more signals.

US Patent:

20200407794, Dec 31, 2020

Filed:

Feb 27, 2019

Appl. No.:

16/975678

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/6883
C12Q 1/6806

Abstract:

The present disclosure provides methods and compositions for evaluation of nucleic acid size distribution and genetic abnormalities. The disclosed methods may be useful in determining size distribution of nucleic acids in a sample, for example, fetal fraction in a plasma sample. The disclosed methods may be useful in identifying or detecting genetic abnormalities from a subject, for example, fetal aneuploidy (e.g., trisomy 21).

US Patent:

20190112636, Apr 18, 2019

Filed:

Feb 8, 2018

Appl. No.:

15/892245

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/686
C12Q 1/6806
C12N 9/22

Abstract:

The present disclosure provides methods and compositions for nucleic acid detection. Nucleic acids may be derived from any source including, for example, viruses, bacterial cells, and eukaryotic cells. The methods of the present disclosure may be used to detect the presence of at least one member of a plurality of nucleic acids in a sample. The methods of the present disclosure may be used to detect the presence of both a first and second member of a plurality of nucleic acids in a sample. Nucleic acids may be detected by the generation of one or more signals.