Christopher S Macdonald

US Patent:

20210292817, Sep 23, 2021

Filed:

Jul 10, 2019

Appl. No.:

17/258880

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/6816
G16B 40/00
G01N 21/64
G01N 21/76

Abstract:

The present disclosure provides methods, systems, and compositions of quantifying one or more analytes in a single sample volume without immobilization, separation, mass spectrometry, or melting curve analysis. Methods may comprise polymerase chain reaction and signal generation to quantify the analytes.

US Patent:

20210087607, Mar 25, 2021

Filed:

May 7, 2020

Appl. No.:

16/869481

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/686
C12N 9/22
C12Q 1/6806
C12Q 1/6823

Abstract:

The present disclosure provides methods and compositions for nucleic acid detection. Nucleic acids may be derived from any source including, for example, viruses, bacterial cells, and eukaryotic cells. The methods of the present disclosure may be used to detect the presence of at least one member of a plurality of nucleic acids in a sample. The methods of the present disclosure may be used to detect the presence of both a first and second member of a plurality of nucleic acids in a sample. Nucleic acids may be detected by the generation of one or more signals.

US Patent:

20200407794, Dec 31, 2020

Filed:

Feb 27, 2019

Appl. No.:

16/975678

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/6883
C12Q 1/6806

Abstract:

The present disclosure provides methods and compositions for evaluation of nucleic acid size distribution and genetic abnormalities. The disclosed methods may be useful in determining size distribution of nucleic acids in a sample, for example, fetal fraction in a plasma sample. The disclosed methods may be useful in identifying or detecting genetic abnormalities from a subject, for example, fetal aneuploidy (e.g., trisomy 21).

US Patent:

20190112636, Apr 18, 2019

Filed:

Feb 8, 2018

Appl. No.:

15/892245

Inventors:

- Carlsbad CA, US
Christopher MACDONALD - Carlsbad CA, US

International Classification:

C12Q 1/686
C12Q 1/6806
C12N 9/22

Abstract:

The present disclosure provides methods and compositions for nucleic acid detection. Nucleic acids may be derived from any source including, for example, viruses, bacterial cells, and eukaryotic cells. The methods of the present disclosure may be used to detect the presence of at least one member of a plurality of nucleic acids in a sample. The methods of the present disclosure may be used to detect the presence of both a first and second member of a plurality of nucleic acids in a sample. Nucleic acids may be detected by the generation of one or more signals.

US Patent:

20180033744, Feb 1, 2018

Filed:

Jul 26, 2016

Appl. No.:

15/219327

Inventors:

- Waltham MA, US
Adrian D. Williams - Methuen MA, US
Christopher J. MacDonald - Medford MA, US
Kamal Tabatabaie Alavi - Sharon MA, US

Assignee:

Raytheon Company - Waltham MA

International Classification:

H01L 23/64
H01L 21/768
H01L 21/324
H01L 23/58

Abstract:

A method and structure, the structure having a substrate, an active device in an active device semiconductor region; of the substrate, a microwave transmission line, on the substrate, electrically connected to the active device, and microwave energy absorbing “dummy” fill elements on the substrate. The method includes providing a structure having a substrate, an active device region on a surface of the structure, an ohmic contact material on the active device region, and a plurality of “dummy” fill elements on the surface to provide uniform heating of the substrate during a rapid thermal anneal process, the ohmic contact material and the “dummy” fill elements having the same radiant energy reflectivity. The rapid thermal anneal processing forms an ohmic contact between an ohmic contact material and the active device region and simultaneously converts the “dummy” fill elements into microwave lossy “dummy” fill elements.