Christopher M Mcbride

US Patent:

8202990, Jun 19, 2012

Filed:

Sep 25, 2008

Appl. No.:

12/680142

Inventors:

Christopher McBride - San Diego CA, US
Zhe Nie - San Diego CA, US

Assignee:

Takeda Pharmaceutical Company Limited - Osaka

International Classification:

C07D 487/04

US Classification:

540501

Abstract:

The present invention relates generally to processes of making 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide and Form A of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide.

US Patent:

20090281092, Nov 12, 2009

Filed:

Sep 24, 2008

Appl. No.:

12/237306

Inventors:

Sheldon X. Cao - San Diego CA, US
Victoria Feher - San Diego CA, US
Takashi Ichikawa - Osaka, JP
Benjamin Jones - Cardiff-By-The-Sea CA, US
Stephen W. Kaldor - Del Mar CA, US
Andre A. Kiryanov - San Diego CA, US
Betty Lam - Spring Valley CA, US
Yan Liu - San Diego CA, US
Christopher McBride - San Diego CA, US
Srinivasa Reddy Natala - San Diego CA, US
Zhe Nie - San Diego CA, US
Jeffrey A. Stafford - San Diego CA, US

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED - Osaka

International Classification:

A61K 31/5513
C07D 487/04
A61P 35/00
A61P 29/00
A61P 37/00
A61P 9/00
A61P 25/00
A61P 19/00

US Classification:

514221, 540502

Abstract:

Compounds of the following formula are provided for use with kinases:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

US Patent:

20090291938, Nov 26, 2009

Filed:

Nov 19, 2008

Appl. No.:

12/274213

Inventors:

Sheldon X. Cao - San Diego CA, US
Victoria Feher - San Diego CA, US
Takashi Ichikawa - Tokyo, JP
Benjamin Jones - Cardiff-By-The-Sea CA, US
Stephen W. Kaldor - Del Mar CA, US
Andre A. Kiryanov - San Diego CA, US
Betty Lam - Spring Valley CA, US
Yan Liu - San Diego CA, US
Christopher McBride - San Diego CA, US
Srinivasa Reddy Natala - San Diego CA, US
Zhe Nie - San Diego CA, US
Jeffrey A. Stafford - San Diego CA, US

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED - Osaka

International Classification:

A61K 31/551
C07D 487/04

US Classification:

51421021, 540502, 514221, 514220, 540495, 51421706, 540496

Abstract:

Compounds of the following formula are provided for use with kinases:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

US Patent:

20100075973, Mar 25, 2010

Filed:

Aug 20, 2009

Appl. No.:

12/544419

Inventors:

Sheldon X. Cao - San Diego CA, US
Takashi Ichikawa - Tokyo, JP
Andre A. Kiryanov - San Diego CA, US
Christopher McBride - San Diego CA, US
Srinivasa Reddy Natala - San Diego CA, US
Stephen W. Kaldor - Del Mar CA, US
Jeffrey A. Stafford - San Diego CA, US

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED - Osaka

International Classification:

A61K 31/5025
C07D 471/14
A61P 35/00

US Classification:

514250, 544251

Abstract:

The present invention provides PLK inhibitors of the formulawherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

US Patent:

20110082111, Apr 7, 2011

Filed:

Dec 7, 2010

Appl. No.:

12/962557

Inventors:

Sheldon X. Cao - San Diego CA, US
Victoria Feher - San Diego CA, US
Takashi Ichikawa - Osaka, JP
Benjamin Jones - Cardiff-By-The-Sea CA, US
Stephen W. KALDOR - Del Mar CA, US
Andre A. KIRYANOV - San Diego CA, US
Betty Lam - Spring Valley CA, US
Yan Liu - San Diego CA, US
Christopher McBride - San Diego CA, US
Srinivasa Reddy Natala - San Diego CA, US
Zhe Nie - San Diego CA, US
Jeffrey A. Stafford - San Diego CA, US

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED - Osaka

International Classification:

A61K 31/675
C07D 487/04
A61K 31/551
A61K 31/397
C07F 9/165
C07D 487/14
C07C 229/34
C07C 229/22
C07C 69/74
C07C 69/75
A61P 35/00

US Classification:

514 81, 540501, 514221, 51421021, 540487, 51421018, 540498, 514220, 540568, 560 47, 560172, 560121, 560125

Abstract:

Compounds of the following formula are provided for use with kinases:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

US Patent:

20120208815, Aug 16, 2012

Filed:

Mar 3, 2008

Appl. No.:

12/449701

Inventors:

Matthew Burger - Albany CA, US
Mika Lindvall - Oakland CA, US
Wooseok Han - San Ramon CA, US
Jiong Lan - Moraga CA, US
Gisele Nishiguchi - Albany CA, US
Cynthia Shafer - Moraga CA, US
Comelia Bellamacina - Castro Valley CA, US
Kay Huh - San Mateo CA, US
Gordana Atallah - Fremont CA, US
Christopher Mcbride - San Diego CA, US
William Antonios-Mccrea, JR. - Moraga CA, US
Tatiana Zavorotinskaya - Moraga CA, US
Annette Walter - Mill Valley CA, US
Pablo Garcia - Oakland CA, US

International Classification:

A61K 31/5377
A61K 31/4545
A61P 35/00
C07D 413/14
A61K 31/496
C07D 417/14
A61K 31/506
A61K 31/497
C07D 401/14
C12N 5/071

US Classification:

5142355, 546194, 514318, 435375, 546193, 544364, 51425301, 546187, 51425211, 544324, 514275, 544405, 51425505, 544130

Abstract:

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

US Patent:

20130224195, Aug 29, 2013

Filed:

Apr 3, 2013

Appl. No.:

13/856225

Inventors:

Abran Costales - El Cerrito CA, US
Teresa Hansen - Danville CA, US
Barry H. Levine - Lafayette CA, US
Christopher McBride - San Diego CA, US
Daniel J. Poon - Piedmont CA, US
Savithri Ramurthy - Walnut Creek CA, US
Paul A. Renhowe - Sudbury MA, US
Cynthia M. Shafer - Moraga CA, US
Sharadha Subramanian - San Ramon CA, US
Joelle Verhagen - Miami FL, US

International Classification:

C07D 401/12
C07D 405/12
C07D 401/14
A61K 31/4545
A61K 31/5377
A61K 45/06
A61K 31/444
C07D 417/12
C07D 417/14
C07D 413/14
A61K 31/551
A61K 31/4439
A61K 31/496

US Classification:

4241331, 5462734, 514338, 546194, 514318, 544131, 5142345, 544364, 51425309, 546256, 514333, 5462701, 51421021, 540575, 514218, 514283, 514 49, 514274, 514249, 424649, 514110, 51425218, 514 34

Abstract:

New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

US Patent:

20220306649, Sep 29, 2022

Filed:

Mar 3, 2022

Appl. No.:

17/686183

Inventors:

- South San Francisco CA, US
James M. VEAL - Apex NC, US
Lynnie Lin TRZOSS - San Diego CA, US
Christopher MCBRIDE - San Diego CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 498/04
A61P 37/02

Abstract:

The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.