Christopher B Mcdaniel

US Patent:

20020169138, Nov 14, 2002

Filed:

Feb 11, 2002

Appl. No.:

10/073744

Inventors:

Lawrence Kunz - Redmond WA, US
Thomas Tice - Hoover AL, US
Randell Libby - Redmond WA, US
Christopher McDaniel - Hoover AL, US

Assignee:

Southern Research Institute

International Classification:

A61K048/00
A61K031/704

US Classification:

514/044000, 514/026000

Abstract:

Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agents.