Christopher D Mcfarland

US Patent:

20220304285, Sep 29, 2022

Filed:

Oct 1, 2019

Appl. No.:

17/281919

Inventors:

- Stanford CA, US
Dmitri Petrov - Stanford CA, US
Ian Winters - Stanford CA, US
Christopher McFarland - Davis CA, US
Zoe Rogers - Menlo Park CA, US

International Classification:

A01K 67/027
C12N 15/11
C12N 9/22
C12N 15/86
C12N 15/10
C12Q 1/6886
G01N 33/50

Abstract:

Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values: and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

US Patent:

20210062184, Mar 4, 2021

Filed:

Sep 10, 2020

Appl. No.:

17/017290

Inventors:

- Stanford CA, US
Dmitri Petrov - Stanford CA, US
Ian P. Winters - Stanford CA, US
Christopher McFarland - Stanford CA, US
Zoe N. Rogers - Menlo Park CA, US

International Classification:

C12N 15/10
C12Q 1/6886

Abstract:

Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

US Patent:

20210009992, Jan 14, 2021

Filed:

Jun 23, 2020

Appl. No.:

16/909806

Inventors:

- Stanford CA, US
Dmitri Petrov - Stanford CA, US
Ian P. Winters - Stanford CA, US
Christopher McFarland - Stanford CA, US
Zoe N. Rogers - Menlo Park CA, US

International Classification:

C12N 15/10
C12Q 1/6886

Abstract:

Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

US Patent:

20190367908, Dec 5, 2019

Filed:

Aug 6, 2019

Appl. No.:

16/533241

Inventors:

- Stanford CA, US
Dmitri Petrov - Stanford CA, US
Ian P. Winters - Stanford CA, US
Christopher McFarland - Stanford CA, US
Zoe N. Rogers - Menlo Park CA, US

International Classification:

C12N 15/10
C12Q 1/6886

Abstract:

Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).

US Patent:

20180282720, Oct 4, 2018

Filed:

Mar 29, 2018

Appl. No.:

15/940818

Inventors:

- Stanford CA, US
Dmitri Petrov - Stanford CA, US
Ian P. Winters - Stanford CA, US
Christopher McFarland - Stanford CA, US
Zoe N. Rogers - Menlo Park CA, US

International Classification:

C12N 15/10
C12Q 1/6886

Abstract:

Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).