A method for cleaning a piece of equipment in place includes a plurality of cleaning cycles and optionally a rinse, where each cleaning cycle includes applying a first cleaning solution from a first supply tank through a first set of nozzles; and applying a second cleaning solution from a second supply tank through a second set of nozzles. The first cleaning solution may be applied for about 20 s to about 10 min, and the second cleaning solution for about 1 min to about 60 min. The cleaning cycle can be repeated from 5 to 150 times, and the first and second cleaning solutions can be recirculated during the process.
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