Christopher S O'Brien

US Patent:

60295244, Feb 29, 2000

Filed:

Jul 8, 1997

Appl. No.:

8/889707

Inventors:

Philip R. Klauder - Ambler PA
James O. Moore - Worcester PA
Christopher J. O'Brien - New Britain PA

Assignee:

Moore Products Co. - Springhouse PA

International Classification:

G01L 912

US Classification:

73718

Abstract:

A pressure transducer having a redundant fluid pressure sensor can be used to determine if the pressure transducer needs to be recalibrated. The pressure transducer comprises a fluid pressure sensor for measuring differential pressure. The fluid pressure sensor includes a pair of substantially identical pressure sensors for providing a variable electrical output as a function of a differential fluid pressure and a reference sensor for providing an electrical output independent of the differential fluid pressure. A conditioning circuit is provided for generating a frequency-based signal whose frequency is a function of the electrical output for each fluid pressure sensor. The electrical output of the first and second pressure sensors can be compared to determine whether the pressure transducer needs to be calibrated. In one embodiment, the pressure sensors comprise variable capacitors. The first and second capacitors each have one fixed plate and one movable plate responsive to differential fluid pressure across the movable plate.

US Patent:

56728085, Sep 30, 1997

Filed:

Jun 11, 1996

Appl. No.:

8/661851

Inventors:

Philip R. Klauder - Ambler PA
James O. Moore - Worcester PA
Christopher J. O'Brien - New Britain PA

Assignee:

Moore Products Co. - Spring House PA

International Classification:

G01L 2700

US Classification:

73 4R

Abstract:

A pressure transducer having a redundant fluid pressure sensor can be used to determine if the pressure transducer needs to be recalibrated. The pressure transducer comprises a fluid pressure sensor for measuring differential pressure. The fluid pressure sensor includes a pair of substantially identical pressure sensors for providing a variable electrical output as a function of a differential fluid pressure and a reference sensor for providing an electrical output independent of the differential fluid pressure. A conditioning circuit is provided for generating a frequency-based signal whose frequency is a function of the electrical output for each fluid pressure sensor. The electrical output of the first and second pressure sensors can be compared to determine whether the pressure transducer needs to be calibrated. In one embodiment, the pressure sensors comprise variable capacitors. The first and second capacitors each have one fixed plate and one movable plate responsive to differential fluid pressure across the movable plate.

US Patent:

58047360, Sep 8, 1998

Filed:

Jan 27, 1997

Appl. No.:

8/790253

Inventors:

Philip R. Klauder - Ambler PA
James O. Moore - Worcester PA
Christopher J. O'Brien - New Britain PA

Assignee:

Moore Products Co. - Spring House PA

International Classification:

G01L 912

US Classification:

73724

Abstract:

A pressure transducer having a redundant fluid pressure sensor can be used to determine if the pressure transducer needs to be recalibrated. The pressure transducer comprises a fluid pressure sensor for measuring differential pressure. The fluid pressure sensor includes a pair of substantially identical pressure sensors for providing a variable electrical output as a function of a differential fluid pressure and a reference sensor for providing an electrical output independent of the differential fluid pressure. A conditioning circuit is provided for generating a frequency-based signal whose frequency is a function of the electrical output for each fluid pressure sensor. The electrical output of the first and second pressure sensors can be compared to determine whether the pressure transducer needs to be calibrated. In one embodiment, the pressure sensors comprise variable capacitors. The first and second capacitors each have one fixed plate and one movable plate responsive to differential fluid pressure across the movable plate.

US Patent:

20220372129, Nov 24, 2022

Filed:

May 19, 2022

Appl. No.:

17/748629

Inventors:

- Horsham PA, US
Christopher O'Brien - Lafayette Hill PA, US
Jacqueline Perrigoue - Oreland PA, US
Marion Vetter - Pennington NJ, US

International Classification:

C07K 16/24
A61P 1/04
A61K 38/17
A61K 39/395

Abstract:

A method of treating inflammatory bowel disorders, such as ulcerative colitis, comprises administering an IL-23 inhibitor, such as an anti-IL-23p19 antibody (e.g., guselkumab) and a TNFα inhibitor, such as an anti-TNFα antibody (e.g., golimumab).

US Patent:

20210363234, Nov 25, 2021

Filed:

May 20, 2021

Appl. No.:

17/325743

Inventors:

- Horsham PA, US
Christopher O'Brien - Lafayette Hill PA, US
Jacqueline Perrigoue - Oreland PA, US
Marion Vetter - Spring House PA, US

International Classification:

C07K 16/24
A61P 1/04
A61P 37/02

Abstract:

A method of treating inflammatory bowel disorders, such as ulcerative colitis, comprises administering an IL-23 inhibitor, such as an anti-IL-23p19 antibody (e.g., guselkumab) and a TNF-α inhibitor, such as an anti-TNF-α antibody (e.g., golimumab).

US Patent:

20210253690, Aug 19, 2021

Filed:

Feb 12, 2021

Appl. No.:

17/175129

Inventors:

- Horsham PA, US
Katherine Li - Wallingford PA, US
Colleen Marano - Malvern PA, US
Richard Strauss - Doylestown PA, US
Hongyan Zhang - Malvern PA, US
Christopher O'Brien - Lafayette Hill PA, US
Omoniyi Adedokun - Phoenixville PA, US
Kimberly Shields-Tuttle - West Chester PA, US

International Classification:

C07K 16/24
A61P 1/04

Abstract:

Described are methods and compositions for clinical proven safe and effective treatment of ulcerative colitis, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.

US Patent:

20210115129, Apr 22, 2021

Filed:

Oct 16, 2020

Appl. No.:

17/072298

Inventors:

- Horsham PA, US
Katherine Li - Wallingford PA, US
Colleen Marano - Malvern PA, US
Richard Strauss - Doylestown PA, US
Hongyan Zhang - Malvern PA, US
Christopher O'Brien - Lafayette Hill PA, US
Omoniyi Adedokun - Phoenixville PA, US
Kimberly Shields-Tuttle - West Chester PA, US

International Classification:

C07K 16/24
A61P 1/04
A61K 9/00
A61K 47/22
A61K 47/26
A61K 47/20
A61K 47/18
A61K 39/395

Abstract:

Described are methods and compositions for clinically proven safe and effective treatment of ulcerative colitis according to the product label described herein, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.

US Patent:

20200369761, Nov 26, 2020

Filed:

May 21, 2020

Appl. No.:

16/880118

Inventors:

- Horsham PA, US
Christopher O'Brien - Lafayette Hill PA, US
Jacqueline Perrigoue - Oreland PA, US

International Classification:

C07K 16/24
A61K 9/00
A61P 1/04
A61P 29/00

Abstract:

A method of treating inflammatory bowel disorders, such as ulcerative colitis, comprises administering an IL-23 inhibitor, such as an anti-IL-23p19 antibody (e.g., guselkumab) and a TNF-α inhibitor, such as an anti-TNF-α antibody (e.g., golimumab).