Christopher L Reeves

US Patent:

6503737, Jan 7, 2003

Filed:

Oct 1, 1999

Appl. No.:

09/410551

Inventors:

Christopher Reeves - Orinda CA
Daniel Chu - Santa Clara CA
Chaitan Khosla - Palo Alto CA
Daniel Santi - San Francisco CA
Kai Wu - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P 1962

US Classification:

435 76, 4353201, 4352523, 43525235, 536 231, 536 232

Abstract:

Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

US Patent:

6569867, May 27, 2003

Filed:

May 10, 2001

Appl. No.:

09/853306

Inventors:

Daniel Chu - Santa Clara CA
Maria Fardis - San Carlos CA
Chaitan Khosla - Palo Alto CA
Christopher Reeves - Orinda CA
Daniel Santi - San Francisco CA
Andreas Schirmer - Hayward CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D49816

US Classification:

514291, 540456

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a âmacrolidesâ or âmacrolactonesâ) that include as part of their structure and bind to a FK binding protein wherein R and R are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R and R is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

US Patent:

6624302, Sep 23, 2003

Filed:

Dec 27, 2002

Appl. No.:

10/331047

Inventors:

Daniel Chu - Santa Clara CA
Maria Fardis - San Carlos CA
Chaitan Khosla - Palo Alto CA
Christopher Reeves - Orinda CA
Daniel Santi - San Francisco CA
Andreas Schirmer - Hayward CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D49816

US Classification:

540456

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a âmacrolidesâ or âmacrolactonesâ) that include as part of their structure and bind to a FK binding protein wherein R and R are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R and R is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

US Patent:

6660862, Dec 9, 2003

Filed:

Apr 3, 2001

Appl. No.:

09/825621

Inventors:

Christopher Reeves - Orinda CA
Daniel Chu - Santa Clara CA
Chaitan Khosla - Palo Alto CA
Daniel Santi - San Francisco CA
Kai Wu - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D51500

US Classification:

546 92

Abstract:

Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.

US Patent:

6759536, Jul 6, 2004

Filed:

Aug 27, 2001

Appl. No.:

09/940316

Inventors:

Christopher Reeves - Orinda CA
Daniel Chu - Santa Clara CA
Chaitan Khosla - Palo Alto CA
Daniel Santi - San Francisco CA
Kai Wu - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D22118

US Classification:

546 71

Abstract:

Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

US Patent:

RE39762, Aug 7, 2007

Filed:

Dec 9, 2005

Appl. No.:

11/299244

Inventors:

Christopher Reeves - Orinda CA, US
Daniel Chu - Santa Clara CA, US
Chaitan Khosla - Palo Alto CA, US
Daniel Santi - San Francisco CA, US
Kai Wu - Foster City CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D 515/00
C07D 498/00

US Classification:

546 92, 546 90

Abstract:

Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.

US Patent:

7285405, Oct 23, 2007

Filed:

Apr 18, 2005

Appl. No.:

11/109593

Inventors:

Christopher D. Reeves - Orinda CA, US
Ralph C. Reid - San Rafael CA, US

Assignee:

Kosan Biosciences Incorporated - Hayward CA

International Classification:

C12N 9/00

US Classification:

435183, 435193, 435189, 435232, 435197

Abstract:

Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides using the polynucleotides encoding jerangolid synthase domains or modifying enzymes.

US Patent:

7332576, Feb 19, 2008

Filed:

Mar 7, 2005

Appl. No.:

11/075185

Inventors:

Christopher D. Reeves - Orinda CA, US
Bryan Julien - Oakland CA, US
Ralph C. Reid - San Rafael CA, US

Assignee:

Kosan Biosciences Inc. - Hayward CA

International Classification:

C07K 1/00

US Classification:

530350, 530300, 435 71, 435 691

Abstract:

Domains of ambruticin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare ambruticin in pharmaceutically useful quantities are described, as are methods to prepare ambruticin analogs and other polyketides using the polynucleotides encoding ambruticin synthase domains or modifying enzymes.