Christopher J Rhodes

US Patent:

6428771, Aug 6, 2002

Filed:

May 15, 1995

Appl. No.:

08/441378

Inventors:

Solomon S. Steiner - Mt. Kisco NY
Robert Feldstein - Dobbs Ferry NY
Huiling Lian - Yonkers NY
Christopher A. Rhodes - Stamford CT
Gregory S. Shen - Hartsdale NY

Assignee:

Pharmaceutical Discovery Corporation - Elmsford NY

International Classification:

A61K 912

US Classification:

424 45, 424 46, 424489

Abstract:

Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0. 5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6. 4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6. 4 or less and unstable at pH of greater than 6. 4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6. 4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

US Patent:

8394414, Mar 12, 2013

Filed:

Nov 12, 2003

Appl. No.:

10/706243

Inventors:

Solomon S. Steiner - Mt. Kisco NY, US
Robert Feldstein - Yonkers NY, US
Huiling Lian - Yonkers NY, US
Christopher A. Rhodes - Ellicott City MD, US
Gregory S. Shen - Hartsdale NY, US

Assignee:

MannKind Corporation - Valencia CA

International Classification:

A61K 9/16

US Classification:

424493, 424489, 424490

Abstract:

Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0. 5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6. 4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6. 4 or less and unstable at pH of greater than 6. 4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6. 4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

US Patent:

60714972, Jun 6, 2000

Filed:

Apr 24, 1997

Appl. No.:

8/847352

Inventors:

Solomon S. Steiner - Mt. Kisco NY
Robert Feldstein - Dobbs Ferry NY
Huiling Lian - Yonkers NY
Christopher A. Rhodes - Stamford CT
Gregory S. Shen - Hartsdale NY

Assignee:

Pharmaceutical Discovery Corporation - Elmsford NY

International Classification:

A61K 912

US Classification:

424 45

Abstract:

Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0. 5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6. 4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6. 4 or less and unstable at pH of greater than 6. 4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6. 4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

US Patent:

20150265541, Sep 24, 2015

Filed:

Sep 20, 2013

Appl. No.:

14/429304

Inventors:

- West Lafayette IN, US
Christopher A. Rhodes - New York NY, US

International Classification:

A61K 9/50
A61K 31/704
A61K 9/48
A61K 9/00

Abstract:

Biodegradable microcapsules include a biodegradable polymer shell and filling material. The polymer shell completely encompasses the filling material. The filling material may include one or more biodegradable microparticles or a therapeutic agent or both.