Christopher M Richardson

US Patent:

7274183, Sep 25, 2007

Filed:

Nov 2, 2005

Appl. No.:

11/265783

Inventors:

Wei Gu - Sunnyvale CA, US
Christopher B. Richardson - Sunnyvale CA, US

Assignee:

National Semiconductor Corporation - Santa Clara CA

International Classification:

G05F 1/40

US Classification:

323288

Abstract:

The present invention provides a versatile system for providing a current-mode switching controller—in low voltage commercial semiconductor technologies—that is compatible with applications having very high input voltage ranges. The system provides an output transistor and a sense element coupled to the output transistor. A waveform representative of current charging across the sense element is recognized. First and second charging elements are provided, and the second charging element is adapted to charge at a rate twice as fast as the first charging element. First and second switching elements, coupled to the first and second charging elements, respectively, are adapted to activate the first and second charging elements responsive to a rising edge of the waveform. An output charge element is provided, and a sample and hold construct is adapted to transfer a charge value—to the output charge element—that corresponds to an average of the charge values of the first and second charging elements upon a falling edge of the waveform.

US Patent:

7486063, Feb 3, 2009

Filed:

Sep 24, 2007

Appl. No.:

11/903737

Inventors:

Wei Gu - Sunnyvale CA, US
Christopher B. Richardson - Sunnyvale CA, US

Assignee:

National Semiconductor Corporation - Santa Clara CA

International Classification:

G05F 1/40

US Classification:

323288, 323284

Abstract:

The present invention provides a versatile system for providing a current-mode switching controller—in low voltage commercial semiconductor technologies—that is compatible with applications having very high input voltage ranges. The system provides an output transistor and a sense element coupled to the output transistor. A waveform representative of current charging across the sense element is recognized. First and second charging elements are provided, and the second charging element is adapted to charge at a rate twice as fast as the first charging element. First and second switching elements, coupled to the first and second charging elements, respectively, are adapted to activate the first and second charging elements responsive to a rising edge of the waveform. An output charge element is provided, and a sample and hold construct is adapted to transfer a charge value—to the output charge element—that corresponds to an average of the charge values of the first and second charging elements upon a falling edge of the waveform.

US Patent:

20190010519, Jan 10, 2019

Filed:

Jan 11, 2017

Appl. No.:

16/067750

Inventors:

- Oakland CA, US
Christopher D. Richardson - San Francisco CA, US
Graham Jordan Ray - San Francisco CA, US

International Classification:

C12N 15/90
C12N 9/22
C12N 15/11

Abstract:

The present disclosure provides methods and compositions for enhanced editing of genomic DNA. For example, in some embodiments, a subject method is a method of editing genomic DNA of a eukaryotic cell and the method includes introducing into a eukaryotic cell a composition comprising: (a) a linearized non-homologous DNA composition and (b) a genome targeting composition (which includes a genome editing endonuclease, or a nucleic acid encoding the genome editing endonuclease). In some cases in which the genome editing endonuclease is a CRISPR/Cas endonuclease, the genome targeting composition can also include a corresponding CRISPR/Cas guide RNA.

US Patent:

20180320202, Nov 8, 2018

Filed:

Dec 1, 2016

Appl. No.:

15/773543

Inventors:

- Oakland CA, US
Christopher D. Richardson - Berkeley CA, US

International Classification:

C12N 15/90
C12N 15/11
C12N 9/22

Abstract:

The present disclosure provides a system for editing genomic DNA, the system comprising an asymmetric donor DNA template; and methods of editing genomic DNA involving use of an asymmetric donor DNA template. The present disclosure provides a system for editing genomic DNA, the system comprising a Cas9 polypeptide with reduced enzymatic activity; and methods of editing genomic DNA involving use of a Cas9 polypeptide with reduced enzymatic activity.