Michael A. HANSON - San Marcos CA, US Christopher B. Roth - San Diego CA, US Raymond C. Stevens - La Jolla CA, US Joshua M. Kunken - San Diego CA, US Mark T. Griffith - San Diego CA, US Aaron A. Thompson - San Diego CA, US Wei Liu - San Diego CA, US Fei Xu - Palm Beach Gardens FL, US Vsevolod Katritch - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA RECEPTOS, INC. - San Diego CA
International Classification:
C12N 9/96 G06F 17/30 C07K 19/00
US Classification:
435188, 530350, 707769
Abstract:
GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described.
Jefferson University PhysiciansMethodist Hospital Radiology 2301 S Broad St FL 2, Philadelphia, PA 19148 (215)9529148 (phone), (215)9529965 (fax)
Jefferson University PhysiciansJefferson Imaging Doylestown MRI 800 W State St STE 203, Doylestown, PA 18901 (215)3454568 (phone), (215)2300938 (fax)
Jefferson Outpatient Imaging 1 W Germantown Pike, Norristown, PA 19401 (610)2773202 (phone), (610)2779640 (fax)
Education:
Medical School Virginia Commonwealth University SOM Graduated: 1997
Languages:
English
Description:
Dr. Roth graduated from the Virginia Commonwealth University SOM in 1997. He works in Philadelphia, PA and 2 other locations and specializes in Diagnostic Radiology and Radiology. Dr. Roth is affiliated with Thomas Jefferson University Hospital and Thomas Jefferson University Hospitals Methodist.
Dr. Roth graduated from the Louisiana State University School of Medicine at Shreveport in 2002. He works in New Orleans, LA and 1 other location and specializes in Pediatric Urology. Dr. Roth is affiliated with Childrens Hospital.
First Financial Credit Union Jun 2014 - Sep 2014
Assistant Branch Manager
Atlantic Medical Supply Mar 2012 - Jan 2014
Accountant
Nyff Events Jan 2002 - Jan 2014
Special Event Coordinator
Capital One Jan 2013 - Oct 2013
Small Business Banker
Ymca of San Diego County Jun 2011 - Aug 2012
Board Member
Education:
University of Phoenix 2012 - 2012
Bachelors, Bachelor of Science, Accounting
Nassau Community College 2003 - 2003
Associates, Associate of Arts
Lindenhurst H.s
Skills:
Loans Management Finance Portfolio Management Banking Cash Management Risk Management Credit Credit Analysis Small Business Credit Facilities Commercial Lending Mortgage Lending Cash Flow Analysis Consumer Credit Facilities Treasury Management Cash Flow Sports Coaching Youth Development Debt Service Analysis Risk Assessment Commercial Banking Small Business Lending Entrepreneurship Natural Gas Account Management Accounts Payable Accounts Receivable Account Reconciliation
Interests:
Weight Training Volunteerism Ny Giants Football Swimming Golf Public Service
Studio City, Ca.Motion Picture film editor since 1987 (Killer Klowns From Outer Space) to present. Theatrical release of Hatchet last year. Premiere of Anthony C. Ferrante... Motion Picture film editor since 1987 (Killer Klowns From Outer Space) to present. Theatrical release of Hatchet last year. Premiere of Anthony C. Ferrante film Headless Horseman on Sci Fi last October. Upcoming premiere of Gary Jones's film Ghouls on Sci Fi July 12, both from Ken Badish, Active...