Christopher W Rysenga

US Patent:

20030186394, Oct 2, 2003

Filed:

Feb 14, 2003

Appl. No.:

10/367225

Inventors:

Kevin Short - Mattawan MI, US
John Ceglarek - Portage MI, US
Christopher Rysenga - Kalamazoo MI, US
Omar Salman - Kalamazoo MI, US
Gregory Mannes - Kalamazoo MI, US
Donald Gillespie - Kalamazoo MI, US

International Classification:

C12P017/18

US Classification:

435/119000

Abstract:

The present invention relates to a process of preparing geldanamycin by culturing in an aqueous nutrient medium. The aqueous nutrient medium can comprise starch, a starch conversion enzyme, an assimilable source of protein and optionally a further assimilable source of carbon or can comprise an assimilable source of carbon and an assimilable source of protein. The present invention also relates to a process for the isolation and purification of geldanamycin.