Christopher D Thompson

US Patent:

20130202626, Aug 8, 2013

Filed:

Jul 27, 2011

Appl. No.:

13/813083

Inventors:

Thomas Linke - Odenton MD, US
William K. Wang - McLean VA, US
Ambarish Shah - Boyds MD, US
Hasige Sathish - Germantown MD, US
Alan Hunter - Gaithersburg MD, US
Christopher Thompson - Gaithersburg MD, US

Assignee:

MEDIMMUNE, LLC - Gaithersburg MD

International Classification:

C07K 1/18
C07K 17/02

US Classification:

4241831, 5303917

Abstract:

The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.

US Patent:

20210395370, Dec 23, 2021

Filed:

Sep 2, 2021

Appl. No.:

17/465092

Inventors:

- Cambridge, GB
William K. WANG - Gaithersburg MD, US
Ambarish SHAH - Gaithersburg MD, US
Hasige SATHISH - Gaithersburg MD, US
Alan HUNTER - Gaithersburg MD, US
Christopher THOMPSON - Gaithersburg MD, US

International Classification:

C07K 16/28
B01D 15/16
B01D 15/36
B01J 41/14
B01J 41/20
A61K 47/68
C07K 1/18
C07K 17/02
A61K 39/395
A61K 47/02

Abstract:

The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

US Patent:

20210248768, Aug 12, 2021

Filed:

Apr 26, 2021

Appl. No.:

17/240307

Inventors:

- San Jose CA, US
Alexander Marques - San Jose CA, US
John Kua - San Francisco CA, US
Aaron Matthew Bestick - San Francisco CA, US
Christopher D. Thompson - Alexandria VA, US
Andrei Claudiu Cosma - Emeryville CA, US

International Classification:

G06T 7/579
G06T 7/73

Abstract:

Motion and video data from vehicle sensors and camera arrays attached to a vehicle collect video and sensor data along a path driven by the vehicle. A system processes such data to produce high-accuracy structured map data, as might be used to precisely locate a moving vehicle in its environment. Positions are calculated from the sensor data. The positions are updated based on the video data. When loops in the vehicle path are detected, a loop closure error is calculated and used to update the positions as well as to reduce bias in the sensors when calculating future positions. Positions of features in the video are used to create or update structured map data.

US Patent:

20200407423, Dec 31, 2020

Filed:

Jun 15, 2020

Appl. No.:

16/901812

Inventors:

- Gaithersburg MD, US
Mariko FONSECA - Gaithersburg MD, US
Christopher THOMPSON - Gaithersburg MD, US
Alan HUNTER - Gaithersburg MD, US
Xiangyang WANG - Gaithersburg MD, US
Liu TIE - Gaithersburg MD, US
Yiming LI - Gaithersburg MD, US

International Classification:

C07K 14/765
A61K 47/64
C07K 1/18
C07K 1/22
C07K 14/78

Abstract:

The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.

US Patent:

20200231680, Jul 23, 2020

Filed:

Feb 10, 2020

Appl. No.:

16/786634

Inventors:

- Cambridge, GB
William K. WANG - Gaithersburg MD, US
Ambarish SHAH - Gaithersburg MD, US
Hasige SATHISH - Gaithersburg MD, US
Alan HUNTER - Gaithersburg MD, US
Christopher THOMPSON - Gaithersburg MD, US

International Classification:

C07K 16/28
B01D 15/16
B01D 15/36
B01J 41/14
B01J 41/20
A61K 47/68
C07K 1/18
C07K 17/02
A61K 39/395
A61K 47/02

Abstract:

The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

US Patent:

20200234459, Jul 23, 2020

Filed:

Jan 22, 2019

Appl. No.:

16/254508

Inventors:

- San Francisco CA, US
Alexander Marques - San Francisco CA, US
John Kua - San Francisco CA, US
Aaron Matthew Bestick - San Francisco CA, US
Christopher D. Thompson - Alexandria VA, US
Andrei Claudiu Cosma - Emeryville CA, US

International Classification:

G06T 7/579
G06T 7/73

Abstract:

Motion and video data from vehicle sensors and camera arrays attached to a vehicle collect video and sensor data along a path driven by the vehicle. A system processes such data to produce high-accuracy structured map data, as might be used to precisely locate a moving vehicle in its environment. Positions are calculated from the sensor data. The positions are updated based on the video data. When loops in the vehicle path are detected, a loop closure error is calculated and used to update the positions as well as to reduce bias in the sensors when calculating future positions. Positions of features in the video are used to create or update structured map data.

US Patent:

20180371094, Dec 27, 2018

Filed:

Sep 7, 2018

Appl. No.:

16/124441

Inventors:

- Gaithersburg MD, US
William K. WANG - Gaithersburg MD, US
Ambarish SHAH - Gaithersburg MD, US
Hasige SATHISH - Gaithersburg MD, US
Alan HUNTER - Gaithersburg MD, US
Christopher THOMPSON - Gaithersburg MD, US

International Classification:

C07K 16/28
A61K 47/68
B01D 15/16

Abstract:

The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

US Patent:

20180203115, Jul 19, 2018

Filed:

Nov 27, 2017

Appl. No.:

15/822285

Inventors:

- Chantilly VA, US
Christopher THOMPSON - Alexandria VA, US

Assignee:

Digital Signal Corporation - Chantilly VA

International Classification:

G01S 17/08
G01S 7/487

Abstract:

Systems and methods for determining ranges to a target disposed behind a transparent surface are described. A target acquisition system receives a plurality of lidar returns, at least some of which are from a target and at least some of which are from a transparent surface. The lidar returns correspond to a portion of a lidar signal generated by a lidar, directed toward the target, and reflected back to the lidar from either the target or the transparent surface. A range measurement for each of the plurality of lidar returns is determined. The target acquisition system generates a histogram of the range measurements. The histogram includes an array including a plurality of range bins. Each range bin defines a unique portion of a predetermined distance out from the lidar. The histogram further includes a count associated with each respective range bin. The count corresponds to a number of range measurements falling within the unique portion of the predetermined distance corresponding to that respective range bin. In some implementations of the invention, the target acquisition system determines which of the range measurements correspond to the target based on the histogram. In some implementations of the invention, the target acquisition system determines which of the range measurements correspond to the transparent surface based on the histogram.