Chuan X Wang

US Patent:

20220348875, Nov 3, 2022

Filed:

Dec 17, 2021

Appl. No.:

17/645004

Inventors:

- Florham Park NJ, US
Qian Ye - Florham Park NJ, US
Tianjian Li - Belle Mead NJ, US
Chuan Wang - Montville NJ, US
Mini Bharathan - Berkeley Heights NJ, US
Uri Herzberg - Bridgewater NJ, US
Robert J. HARIRI - Bernardsville NJ, US

Assignee:

Celularity Inc. - Florham Park NJ

International Classification:

C12N 5/0783
A61K 35/17
C07K 14/735
A61K 45/06
A61P 35/00

Abstract:

Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.