Chun Yan Li

US Patent:

6441025, Aug 27, 2002

Filed:

Mar 30, 1998

Appl. No.:

09/050662

Inventors:

Chun Li - Missouri City TX
Sidney Wallace - Houston TX
Dong-Fang Yu - Houston TX
David J. Yang - Sugar Land TX

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A01N 4302

US Classification:

514449

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

6515017, Feb 4, 2003

Filed:

May 24, 2002

Appl. No.:

10/153818

Inventors:

Chun Li - Missouri City TX
Sidney Wallace - Houston TX
Dong-Fang Yu - Houston TX
David Yang - Sugar Land TX

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A61K 31335

US Classification:

514449, 600 1

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

6730699, May 4, 2004

Filed:

Nov 20, 2002

Appl. No.:

10/300031

Inventors:

Chun Li - Missouri City TX
Sidney Wallace - Houston TX
Dong-Fang Yu - Houston TX
David Yang - Sugar Land TX

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A61K 31335

US Classification:

514449, 514510, 514511, 424486

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

6884817, Apr 26, 2005

Filed:

May 17, 2002

Appl. No.:

10/146809

Inventors:

Chun Li - Missouri City TX, US
Sidney Wallace - Bellaire TX, US
Dong-Fang Yu - Houston TX, US
David J. Yang - Sugar Land TX, US

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A61N043/02
A61N055/02
A61N037/00
A61K031/30
A61K033/24

US Classification:

514449, 514492, 514500, 514510, 514511, 424649

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

7060724, Jun 13, 2006

Filed:

Jan 30, 2003

Appl. No.:

10/354431

Inventors:

Chun Li - Missouri City TX, US
Sidney Wallace - Houston TX, US
Dong-Fang Yu - Houston TX, US
David J. Yang - Sugar Land TX, US

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A01N 43/02
C07D 305/00

US Classification:

514449, 549510, 549511

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

7135496, Nov 14, 2006

Filed:

Oct 28, 2002

Appl. No.:

10/282490

Inventors:

Chun Li - Missouri City TX, US
Sidney Wallace - Houston TX, US
Dong-Fang Yu - Houston TX, US
David Yang - Sugar Land TX, US

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A01N 37/00
A61K 31/21

US Classification:

514511, 514449

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

US Patent:

7371364, May 13, 2008

Filed:

Aug 13, 2004

Appl. No.:

10/918009

Inventors:

Chun Li - Missouri City TX, US
Wei Wang - Sugar Land TX, US
Shi Ke - Missouri City TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 51/00
A61K 38/00
A61K 38/12
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00

US Classification:

424 169, 514 9, 530317

Abstract:

The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.

US Patent:

7384977, Jun 10, 2008

Filed:

Aug 31, 2006

Appl. No.:

11/513390

Inventors:

Chun Li - Missouri City TX, US
Sidney Wallace - Houston TX, US
Dong-Fang Yu - Houston TX, US
David J. Yang - Sugar Land TX, US

Assignee:

PG-TXL Company, L.P. - Houston TX

International Classification:

A01N 37/00
A61K 31/21

US Classification:

514511, 424 111, 424 165, 424 91, 424 169, 514510, 514449

Abstract:

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.