Chun T Lin

US Patent:

49719785, Nov 20, 1990

Filed:

Aug 22, 1988

Appl. No.:

7/234525

Inventors:

Alex M. Nadzan - Libertyville IL
James F. Kerwin - Mundelein IL
Chun W. Lin - Wood Dale IL

International Classification:

C07D21522
A61K 3147

US Classification:

514312

Abstract:

A compound of the formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are substituents; R. sub. 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O). sub. 2 ; Ar is a heterocyclic group; and n is 1 to 3. Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.

US Patent:

51283468, Jul 7, 1992

Filed:

Aug 23, 1990

Appl. No.:

7/571945

Inventors:

Alex M. Nadzan - Libertyville IL
James F. Kerwin - Mundelein IL
Chun W. Lin - Wood Dale IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

H01N 4342
C07D20904

US Classification:

514307

Abstract:

A compound of the formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are substituents; R. sub. 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O). sub. 2 ; Ar is a heterocyclic group; and n is 1 to 3. Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.

US Patent:

52703029, Dec 14, 1993

Filed:

Jun 17, 1991

Appl. No.:

7/713010

Inventors:

Kazumi Shiosaki - Libertyville IL
Alex M. Nadzan - Libertyville IL
Hana Kopecka - Vernon Hills IL
Youe-Kong Shue - Vernon Hills IL
Mark W. Holladay - Vernon Hills IL
Chun W. Lin - Wood Dale IL
Hugh N. Nellans - Mundelein IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3702
C07K 508
C07K 510

US Classification:

514 18

Abstract:

Selective and potent Type-A CCK receptor agonists of formula (I): X--Y--Z--Q (I) or a pharmaceutically acceptable salt thereof, wherein, X is selected from ##STR1## Y is selected from ##STR2## Z is ##STR3## and Q is ##STR4## or pharmaceutically-acceptable salts thereof, useful in the treatment of gastrointestinal disorders (including gallbladder disorders), central nervous system disorders, insulin-related disorders and pain, as well as in appetite regulation.