Chun Y Wu

US Patent:

20170276664, Sep 28, 2017

Filed:

Jun 12, 2017

Appl. No.:

15/619853

Inventors:

- Oakland CA, US
Jolie McLane - Newport Beach CA, US
Chun Wu - Rowland Heights CA, US

International Classification:

G01N 33/493
B01L 3/00
G01N 21/05
G01N 21/25
G01N 33/68
G01N 21/03

Abstract:

This disclosure provides a diagnostic system including a detection zone adapted to receive a volume of biological fluid. The detection zone includes a plurality of micro-scale and nano-scale features that render the detection zone superhydrophobic. Analytes (e.g., proteins and/or other molecules) are concentrated when the volume of biological fluid is allowed to evaporate on the detection zone. Concentrating the analytes in the detection zone by evaporation can advantageously increase the sensitivity of detection of the analyte. In various implementations, microfluidic channels can be integrated with the diagnostic system to convey the volume of biological fluid to the detection zone. In various implementations, the microfluidic channels can have a lower hydrophobic characteristic than the surrounding to realize self-driven microfluidic channels that convey the biological fluid to the detection zone without using any external devices.

US Patent:

20160169867, Jun 16, 2016

Filed:

Jan 7, 2015

Appl. No.:

14/591825

Inventors:

- Oakland CA, US
Jolie McLane - Newport Beach CA, US
Chun Wu - Rowland Heights CA, US

International Classification:

G01N 33/493
B01L 3/00
G01N 21/25
G01N 33/68

Abstract:

This disclosure provides a diagnostic system including a detection zone adapted to receive a volume of biological fluid. The detection zone includes a plurality of micro-scale and nano-scale features that render the detection zone superhydrophobic. Analytes (e.g., proteins and/or other molecules) are concentrated when the volume of biological fluid is allowed to evaporate on the detection zone. Concentrating the analytes in the detection zone by evaporation can advantageously increase the sensitivity of detection of the analyte. In various implementations, microfluidic channels can be integrated with the diagnostic system to convey the volume of biological fluid to the detection zone. In various implementations, the microfluidic channels can have a lower hydrophobic characteristic than the surrounding to realize self-driven microfluidic channels that convey the biological fluid to the detection zone without using any external devices.