Chung Hsien Lu

US Patent:

20100279353, Nov 4, 2010

Filed:

Apr 30, 2009

Appl. No.:

12/387340

Inventors:

Shiu Nan Chen - San Marino CA, US
Chung Lun Lu - San Marino CA, US
Jung Fu Wu - San Marcos CA, US
Sherwin Chen - San Marino CA, US

International Classification:

C12P 21/04
C12N 9/02

US Classification:

435 701, 435189

Abstract:

A fibrinolytic enzyme isolated from a culture broth of a mushroom has a characteristic of degrading a fibrin and a fibrinogen without activating an activity of a plasminogen. The plasminogen is activated to generate a plasmin to degrade the fibrin and/or fibrinogen, so that the fibrinolytic enzyme be used for the thrombosis-related diseases to degrade the fibrin and fibrinogen of blood clots without activate the plasminogen, so as to avoid a hemorrhage due to the over activation the plasminogen to over generate the plasmin.