Cindy H Yang

US Patent:

20210145957, May 20, 2021

Filed:

Jan 28, 2021

Appl. No.:

17/161119

Inventors:

- New York NY, US
Amardeep Singh Bhupender Bhalla - Montvale NJ, US
Robert G.K. Donald - South Orange NJ, US
Jianxin Gu - Paramus NJ, US
Kathrin Ute Jansen - New York NY, US
Rajesh Kumar Kainthan - Tappan NY, US
Lakshmi Khandke - Nanuet NY, US
Jin-Hwan Kim - Suffern NY, US
Paul Liberator - Holmdel NJ, US
Avvari Krishna Prasad - Chapel Hill NC, US
Mark Edward Ruppen - Cresco PA, US
Ingrid Lea Scully - Cornwall NY, US
Suddham Singh - Monroe NY, US
Cindy Xudong Yang - Tappan NY, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 39/09
C07K 16/12
C07K 16/44
A61K 39/39
A61K 39/40
A61K 47/10
A61K 47/26

Abstract:

The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from , commonly referred to as group (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

US Patent:

20200368340, Nov 26, 2020

Filed:

Aug 4, 2020

Appl. No.:

16/984499

Inventors:

- New York NY, US
Leena Shriram Bagle - Edgewater NJ, US
Amardeep Singh Bhupender Bhalla - Montvale NJ, US
Miguel Angel Garcia - Midland Park NJ, US
Lei Hu - New City NY, US
Lakshmi Khandke - Nanuet NY, US
Avvari Krishna Prasad - Chapel Hill NC, US
Cindy Xudong Yang - Tappan NY, US

International Classification:

A61K 39/09
A61K 39/39

Abstract:

The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from , commonly referred to as group B (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

US Patent:

20190142922, May 16, 2019

Filed:

Jan 11, 2019

Appl. No.:

16/245378

Inventors:

- New York NY, US
Amardeep Singh Bhupender Bhalla - Montvale NJ, US
Robert G.K. Donald - South Orange NJ, US
Jianxin Gu - Paramus NJ, US
Kathrin Ute Jansen - New York NY, US
Rajesh Kumar Kainthan - Tappan NY, US
Lakshmi Khandke - Nanuet NY, US
Jin-Hwan Kim - Suffern NY, US
Paul Liberator - Holmdel NJ, US
Avvari Krishna Prasad - Chapel Hill NC, US
Mark Edward Ruppen - Garnerville NY, US
Ingrid Lea Scully - Cornwall NY, US
Suddham Singh - Monroe NY, US
Cindy Xudong Yang - Tappan NY, US

International Classification:

A61K 39/09
A61K 39/40
A61K 47/26
C07K 16/12
C07K 16/44
A61K 47/10
A61K 39/39

Abstract:

The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from , commonly referred to as group B (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

US Patent:

20180125958, May 10, 2018

Filed:

Nov 1, 2017

Appl. No.:

15/800373

Inventors:

- New York NY, US
Leena Shriram Bagle - Edgewater NJ, US
Amardeep Singh Bhupender Bhalla - Montvale NJ, US
Miguel Angel Garcia - Midland Park NJ, US
Lei Hu - New City NY, US
Lakshmi Khandke - Nanuet NY, US
Avvari Krishna Prasad - Chapel Hill NC, US
Cindy Xudong Yang - Tappan NY, US

International Classification:

A61K 39/09
A61K 39/39

Abstract:

The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from commonly referred to as group B (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

US Patent:

20160324950, Nov 10, 2016

Filed:

May 3, 2016

Appl. No.:

15/144884

Inventors:

- New York NY, US
Amardeep Singh Bhupender Bhalla - Montvale NJ, US
Robert G.K. Donald - South Orange NJ, US
Jianxin Gu - Paramus NJ, US
Kathrin Ute Jansen - New York NY, US
Rajesh Kumar Kainthan - Tappan NY, US
Lakshmi Khandke - Nanuet NY, US
Jin-Hwan Kim - Suffern NY, US
Paul Liberator - Holmdel NJ, US
Avvari Krishna Prasad - Chapel Hill NC, US
Mark Edward Ruppen - Garnerville NY, US
Ingrid Lea Scully - Cornwall NY, US
Suddham Singh - Monroe NY, US
Cindy Xudong Yang - Tappan NY, US

International Classification:

A61K 39/09
A61K 39/40
A61K 47/10
A61K 39/39
A61K 47/26

Abstract:

The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from , commonly referred to as group B (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.