Craig K Jordan

US Patent:

20220289707, Sep 15, 2022

Filed:

Jul 2, 2020

Appl. No.:

17/620317

Inventors:

- Denver CO, US
Christopher J. MATHESON - Newcastle upon Tyne, GB
Craig JORDAN - Aurora CO, US

International Classification:

C07D 401/06
A61P 35/02

Abstract:

The present disclosure relates to compounds of Formula (I):stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, e.g., to inhibit AMP-Activated protein kinase (AMPK) and treat cancer in a subject.

US Patent:

20190040077, Feb 7, 2019

Filed:

Jan 27, 2017

Appl. No.:

16/073705

Inventors:

- Little Rock AR, US
- Denver CO, US
Jessica Ponder - Denver CO, US
Craig Jordan - Denver CO, US

International Classification:

C07D 493/04
A61P 35/00
C07C 57/15

Abstract:

The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

US Patent:

20180237458, Aug 23, 2018

Filed:

Apr 19, 2018

Appl. No.:

15/957524

Inventors:

- Little Rock AR, US
- Denver CO, US
Narsimha Reddy Penthala - Little Rock AR, US
Craig Jordan - Denver CO, US
Shobanbabu Bommagani - Little Rock AR, US
Jessica Ponder - Denver CO, US

International Classification:

C07D 519/00
C07F 7/18

Abstract:

The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

US Patent:

20170362254, Dec 21, 2017

Filed:

Dec 3, 2015

Appl. No.:

15/532413

Inventors:

- Little Rock AR, US
Peter Crooks - Little Rock AR, US
Narsimha Reddy Penthala - Little Rock AR, US
Craig Jordan - Denver CO, US
Shobanbabu Bommagani - Little Rock AR, US
Jessica Ponder - Denver CO, US

International Classification:

C07D 519/00
C07F 7/18

Abstract:

The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.

US Patent:

20160368928, Dec 22, 2016

Filed:

Aug 30, 2016

Appl. No.:

15/251889

Inventors:

- Little Rock AR, US
- Aurora CO, US
Narsimha Reddy Penthala - Little Rock AR, US
Craig T. Jordan - Aurora CO, US
Jessica Ponder - Aurora CO, US

International Classification:

C07D 493/04

Abstract:

The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB. These derivatives are useful for treating cancer in humans.

US Patent:

20160115508, Apr 28, 2016

Filed:

Jun 4, 2014

Appl. No.:

14/896221

Inventors:

- Rochester NY, US
Craig T. Jordan - Aurora CO, US
Joshua N. Kolev - Burlington NJ, US

International Classification:

C12P 17/18
C12N 9/02
C07D 493/04

Abstract:

Methods are provided for the generation of parthenolide derivatives functionalized at carbon atoms C9 and C14. Natural cytochrome P450 enzymes, and engineered variants of these enzymes, are used to carry out the hydroxylation of these sites in parthenolide. These P450-catalyzed C—H hydroxylation reactions are coupled to chemical interconversion of the enzymatically introduced hydroxyl group to install a broad range of functionalities at these otherwise unreactive sites of the molecule. The methods can also be used to produce bifunctionalized parthenolide derivatives, which in addition to modifications at the level of carbon atom C9 or C14, are also functionalized at the level of carbon atom C13.

US Patent:

20150203508, Jul 23, 2015

Filed:

Apr 1, 2015

Appl. No.:

14/676537

Inventors:

- Little Rock AR, US
- Aurora CO, US
Narsimha Reddy Penthala - Little Rock AR, US
Craig T. Jordan - Aurora CO, US
Jessica Ponder - Aurora CO, US

International Classification:

C07D 493/04

Abstract:

The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB. These derivatives are useful for treating cancer in humans.