Craig F Thompson

US Patent:

20130288284, Oct 31, 2013

Filed:

Sep 14, 2012

Appl. No.:

13/617332

Inventors:

Leonard Luan C Dang - Boston MA, US
Stefan Gross - Brookline MA, US
Hyun Gyung Jang - Arlington MA, US
Shengfang Jin - Newton MA, US
Shin-San Michael Su - Newton MA, US
Craig Thompson - New York NY, US

International Classification:

C12Q 1/32

US Classification:

435 26

Abstract:

Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).

US Patent:

20220306986, Sep 29, 2022

Filed:

Oct 29, 2021

Appl. No.:

17/514742

Inventors:

- New York NY, US
Craig B. Thompson - New York NY, US
Santosha A. Vardhana - Brooklyn NY, US

Assignee:

MEMORIAL SLOAN-KETTERING CANCER CENTER - New York NY

International Classification:

C12N 5/0735

Abstract:

The present disclosure provides highly efficient, non-invasive, and reversible methods for selectively enriching pluripotent cells (e.g., human pluripotent cells and mouse pluripotent cells) in a cell population using a glutamine-deficient medium. The presently disclosed methods have the advantageous of efficiently enriching pluripotent cells in a heterogenous cell population without altering the biological properties of any individual cells.

US Patent:

20210077529, Mar 18, 2021

Filed:

Apr 16, 2019

Appl. No.:

17/048248

Inventors:

- New York NY, US
Lydia Whitney Stillman Finley - New York NY, US
Craig B. Thompson - New York NY, US

International Classification:

A61K 35/17
A61K 31/198
C12N 5/0783

Abstract:

The present invention provides methods for the induction and monitoring of T cell exhaustion in vitro. The methods are effective for both human and non-human T cells, and for both antigen-specific and polyclonal T cells. The present invention also provides methods to screen for and/or evaluate pharmacologic agents that can either induce or reverse T cell exhaustion. The present invention also provides certain agents that can reverse T cell exhaustion.

US Patent:

20200032315, Jan 30, 2020

Filed:

Jun 25, 2019

Appl. No.:

16/452297

Inventors:

- New York NY, US
Craig B. Thompson - New York NY, US

International Classification:

C12Q 1/32
A61K 31/711
G01N 33/50

Abstract:

The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.

US Patent:

20190276894, Sep 12, 2019

Filed:

Apr 26, 2018

Appl. No.:

15/963784

Inventors:

- Cambridge MA, US
Stefan Gross - Brookline MA, US
Hyun Gyung Jang - Waltham MA, US
Shengfang Jin - Newton MA, US
Shin-San Michael Su - Boston MA, US
Craig Thompson - New York NY, US

International Classification:

C12Q 1/6886
A61K 31/355
A61K 31/375
A61K 31/05
A61K 31/522
A61K 31/713
A61K 31/015
A61K 31/122
A61K 31/194
A61K 38/06
A61K 31/225
A61K 38/44
C12Q 1/32
A61K 31/7004
A61K 31/381

Abstract:

Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).

US Patent:

20190046489, Feb 14, 2019

Filed:

Oct 15, 2018

Appl. No.:

16/160237

Inventors:

- New York NY, US
- Princeton NJ, US
Craig Thompson - New York NY, US
Justin Cross - New York NY, US

International Classification:

A61K 31/20
A23L 33/12
A23L 33/17
A23L 33/115
G01N 33/574
A61K 31/202
A61K 45/06
A23L 33/10
A61K 31/685
A61K 36/889
A61K 31/66

Abstract:

Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.

US Patent:

20170175164, Jun 22, 2017

Filed:

Mar 27, 2015

Appl. No.:

15/129167

Inventors:

- New York NY, US
Craig B. THOMPSON - New York NY, US

Assignee:

MEMORIAL SLOAN-KETTERING CANCER CENTER - New York NY

International Classification:

C12Q 1/32
G01N 33/50

Abstract:

The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.

US Patent:

20170044620, Feb 16, 2017

Filed:

Aug 16, 2016

Appl. No.:

15/238161

Inventors:

- Cambridge MA, US
Stefan Gross - Brookline MA, US
Hyun Gyung Jang - Waltham MA, US
Shengfang Jin - Newton MA, US
Shin-San Michael Su - Newton MA, US
Craig Thompson - New York NY, US

International Classification:

C12Q 1/68
A61K 31/194

Abstract:

Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).