Cristian A Perez

US Patent:

7364867, Apr 29, 2008

Filed:

Apr 13, 2001

Appl. No.:

09/834792

Inventors:

Robert F. Margolskee - Upper Montclair NJ, US
Liquan Huang - New Haven CT, US
Minqing Rong - Brooklyn NY, US
Marianna Max - West Orange NJ, US
Cristian A. Perez - New York NY, US

Assignee:

The Mount Sinai School of Medicine - New York NY

International Classification:

G01N 33/566

US Classification:

435 721, 435 71, 435 72

Abstract:

The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.

US Patent:

7960127, Jun 14, 2011

Filed:

Feb 25, 2008

Appl. No.:

12/036860

Inventors:

Robert F. Margolskee - Upper Montclair NJ, US
Liquan Huang - Havertown PA, US
Minqing Rong - Foster City CA, US
Marianna Max - Montclair NJ, US
Cristian A. Perez - New York NY, US

Assignee:

The Mount Sinai School of Medicine - New York NY

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 72, 436501

Abstract:

The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.

US Patent:

7960128, Jun 14, 2011

Filed:

Mar 7, 2008

Appl. No.:

12/044263

Inventors:

Robert F. Margolskee - Upper Montclair NJ, US
Liquan Huang - Havertown PA, US
Minqing Rong - Foster City CA, US
Marianna Max - Montclair NJ, US
Cristian A. Perez - New York NY, US

Assignee:

The Mount Sinai School of Medicine - New York NY

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 72, 436501

Abstract:

The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.

US Patent:

20060292548, Dec 28, 2006

Filed:

Apr 17, 2006

Appl. No.:

11/405097

Inventors:

Robert Margolskee - Upper Montclair NJ, US
Liquan Huang - Havertown PA, US
Minqing Rong - Foster City CA, US
Marianna Max - Montclair NJ, US
Cristian Perez - New York NY, US

Assignee:

Mount Sinai School of Medicine - New York NY

International Classification:

G01N 33/567
C12Q 1/00
G01N 33/53

US Classification:

435004000, 435007200

Abstract:

The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.