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Us Patents
Method For Fixation Of Biological Tissues Having Mitigated Propensity For Post-Implantation Calcification And Thrombosis And Bioprosthetic Devices Prepared Thereby
Alain F. Carpentier - Paris, FR Sophie Carpentier - Paris, FR Crystal M. Cunanan - Mission Viejo CA Lillian Quintero - Garden Grove CA Michael N. Helmus - Long Beach CA Christine Loshbaugh - Irvine CA H. Chris Sarner - Laguna Hills CA
Assignee:
Edwards Lifesciences Corporation
International Classification:
A61F 202
US Classification:
623 2372, 623915, 623917, 623920, 8 9411
Abstract:
A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e. g. , forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
Method For Producing Improved Medical Devices And Devices So Produced
Neng S. Ung-Chhun - Lincolnshire IL Richard J. Johnson - Mundeline IL Dean Laurin - Chandler AZ Crystal M. Cunanan - Mission Viejo CA
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61F 236
US Classification:
623 2372, 623 2376
Abstract:
Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
Craig Young - Presque Isle ME Glenn R. Sussman - Lake Forest CA Crystal M. Cunanan - Mission Viejo CA
Assignee:
Advanced Medical Optics, Inc. - Santa Ana CA
International Classification:
A61F 216
US Classification:
623 616, 623 617, 623 631
Abstract:
An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.
Delivery Systems For Periadventitial Delivery For Treatment Of Restenosis And Anastomotic Intimal Hyperplasia
Michael N. Helmus - Worcester MA Crystal M. Cunanan - Mission Viejo CA Patrice Tremble - Santa Rosa CA
Assignee:
Edwards Lifesciences Corporation - Irvine CA
International Classification:
A61F 202
US Classification:
424423, 424501, 424502
Abstract:
The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The drug delivery vehicle substantially adheres to the site of administration and provides for the release of a bioactive agent that reduces or prevents further injury to the internal structure by disease processes, such as hyperplasia.
Methods For Quantitative And Qualitative Analyses Of Phospholipids Using One-Dimensional Thin Layer Chromatography
A highly sensitive and specific method for the detection and quantification of lipids is provided. Specifically, methods for the simultaneous detection and quantification of phospholipids extracted from mammalian tissues is described. The analytical methods provided disclose a modified one-dimensional thin-layer chromatography technique specifically developed to rapidly and accurantely detect and quantify phospholipids from mammalian cardiac tissues.
Delivery Systems For Periadventitial Delivery For Treatment Of Restenosis And Anastomotic Intimal Hyperplasia
Michael N. Helmus - Worcester MA, US Crystal M. Cunanan - Mission Viejo CA, US Patrice Tremble - Santa Rosa CA, US
Assignee:
Edwards Lifesciences Corporation - Irvine CA
International Classification:
A61F 2/02 A61K 9/50
US Classification:
424423, 424501, 424502
Abstract:
The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The drug delivery vehicle substantially adheres to the site of administration and provides for the release of a bioactive agent that reduces or prevents further injury to the internal structure by disease processes, such as hyperplasia.
Method For Treatment Of Biological Tissues To Mitigate Post-Implantation Calcification And Thrombosis
Alain F. Carpentier - Paris, FR Sophie Carpentier - Paris, FR Crystal M. Cunanan - Mission Viejo CA, US Lillian J. Quintero - Chester NY, US Michael N. Helmus - Worcester MA, US Christine Loshbaugh - Irvine CA, US H. Chris Sarner - Laguna Hills CA, US
A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50 C. for a time period of about 1 to 2 days. The method of treating a biological tissue may be utilized as a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e. g. , forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method. The aqueous sterilizing solution may be glutaraldehyde of about 0. 625 weight percent buffered to a pH of about 7. 4.
Medical Devices And Products Having Coatings Applied Thereto
Neng S. Ung-Chhun - Lincolnshire IL, US Richard J. Johnson - Mundeline IL, US Dean Laurin - Chandler AZ, US Crystal M. Cunanan - Mission Viejo CA, US
Assignee:
Edwards Lifesciences Corporation - Irvine CA
International Classification:
A61F 2/02
US Classification:
623 2372, 427 224
Abstract:
Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
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