Cynthia Nicole Burrows

US Patent:

52720560, Dec 21, 1993

Filed:

Jan 3, 1991

Appl. No.:

7/637163

Inventors:

Cynthia J. Burrows - Stony Brook NY
Steven E. Rokita - Port Jefferson NY
Xiaoying Chen - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C12Q 168

US Classification:

435 6

US Patent:

51264641, Jun 30, 1992

Filed:

Oct 29, 1990

Appl. No.:

7/605249

Inventors:

Cynthia Burrows - Stony Brook NY
Thomas R. Wagler - Chatham NY
Heungsik Yoon - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07D30103

US Classification:

549520

Abstract:

A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1## wherein: n=0 or 1; m=0 or 1; n+m>0; X. sub. 1, X. sub. 2, Z. sub. 1 and Z. sub. 2 independently represent H. sub. 2 or O; Y. sub. 1, Y. sub. 2, Y. sub. 3 and Y. sub. 4 independently represent H, lower alkyl or CH. sub. 2 COOH; L. sub. 1 and L. sub. 2 independently represent side chains of alpha amino acids, except that L. sub. 1 and L. sub. 2 do not both represent H; and R. sub. 1 and R. sub. 2 independently represent H or OH forms stable complexes with transition metal ions that may be used as catalysts for oxidizing alkenes to epoxides with oxidizing agents. A method is also provided for oxidizing alkenes to epoxides by treating the alkene with a transition metal ion complex which includes the 13 or 14 member macrocyclic compound of the invention, a cyclam or a Schiff base complex and peroxymonosulfate ion or hypochlorite ion in a two phase system comprising a phase transfer catalyst, a water phase having a pH from about 6 to about 14 and an inorganic solvent phase in which the complex is sufficiently soluble.

US Patent:

54281806, Jun 27, 1995

Filed:

Dec 10, 1993

Appl. No.:

8/165063

Inventors:

Cynthia Burrows - Stony Brook NY
Thomas R. Wagler - Chatham NJ
Heungsik Yoon - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07D30103
C07D30112

US Classification:

549520

Abstract:

A method is provided for oxidizing alkenes to epoxides by treating the alkene with a transition metal ion complex which includes a salen or salophen derivative and peroxymonosulfate ion or hypochlorite ion in a two phase system with a phase transfer catalyst, a water phase having a pH from about 6 to about 12. 9 and an inorganic solvent phase in which the complex is sufficiently soluble.

US Patent:

55040756, Apr 2, 1996

Filed:

Sep 28, 1993

Appl. No.:

8/128308

Inventors:

Cynthia J. Burrows - Stony Brook NY
Steven E. Rokita - Port Jefferson NY
Xiaoying Chen - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

A01N 5502

US Classification:

514189

Abstract:

A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.

US Patent:

49872273, Jan 22, 1991

Filed:

Feb 23, 1990

Appl. No.:

7/484102

Inventors:

Cynthia Burrows - Stony Brook NY
Heungsik Yoon - Stony Brook NY
Thomas R. Wagler - Chatham NJ

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07D25702

US Classification:

540452

Abstract:

A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1## This work was supported by grants from the National Institutes of Health (GM-34841) and the National Science Foundation (CHE-8706616).