Cynthia J Burrows

US Patent:

7371579, May 13, 2008

Filed:

Jul 3, 2000

Appl. No.:

10/019655

Inventors:

Steven E. Rokita - Silver Spring MD, US
Cynthia J. Burrows - Salt Lake City UT, US

Assignee:

The University of Maryland - College Park MD

International Classification:

C07D 235/02
C07F 15/04
C07K 2/00
G01N 33/52
G01N 33/58
G01N 33/60
G01N 33/68
C07K 14/795

US Classification:

436 86, 436 94, 530300, 530400, 534 10, 534 12, 536 254, 540145

Abstract:

The invention relates to a compound comprising a labeled nickel complex (FIG. ) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified through a separation process, such as affinity chromatography.

US Patent:

20120091005, Apr 19, 2012

Filed:

Sep 7, 2011

Appl. No.:

13/227212

Inventors:

Cynthia J. Burrows - Salt Lake City UT, US
Henry S. White - Salt Lake City UT, US
Ryuji Kawano - Salt Lake City UT, US
Aaron M. Fleming - Salt Lake City UT, US
Na An - Salt Lake City UT, US

International Classification:

G01N 33/559
C07K 2/00
G01N 27/447
C07H 21/00
C07H 23/00
B82Y 99/00
B82Y 5/00

US Classification:

204605, 536 231, 527313, 530322, 204456, 204606, 977700, 977962

Abstract:

Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.

US Patent:

20120095077, Apr 19, 2012

Filed:

Mar 23, 2010

Appl. No.:

13/257093

Inventors:

Cynthia J. Burrows - Salt Lake City UT, US
Arunkumar Kannan - Salt Lake City UT, US
Peter A. Beal - Davis CA, US

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

International Classification:

A61K 31/7088
C07H 19/167
C07D 473/18
C07H 21/02

US Classification:

514 44 A, 536 245, 536 2781, 544276

Abstract:

Disclosed are compositions and methods related to modified nucleobases. Also disclosed are compositions and methods related to modified interfering RNAs. Also disclosed are compositions and methods related to modified guanine bases for controlling off-target effects in RNA interference.

US Patent:

20130102652, Apr 25, 2013

Filed:

Mar 23, 2011

Appl. No.:

13/636295

Inventors:

Cynthia J. Burrows - Salt Lake City UT, US
Uday Ghanty - Salt Lake City UT, US

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

International Classification:

C12N 15/113
C07H 23/00
C07H 19/20

US Classification:

514 44 A, 536 267, 536 245

Abstract:

Disclosed are compositions and methods related to modified nucleobases. Also disclosed are compositions and methods related to modified interfering RNAs. Also disclosed are compositions and methods related to modified adenonsine for controlling off-target effects in RNA interference.

US Patent:

52720560, Dec 21, 1993

Filed:

Jan 3, 1991

Appl. No.:

7/637163

Inventors:

Cynthia J. Burrows - Stony Brook NY
Steven E. Rokita - Port Jefferson NY
Xiaoying Chen - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C12Q 168

US Classification:

435 6

US Patent:

51264641, Jun 30, 1992

Filed:

Oct 29, 1990

Appl. No.:

7/605249

Inventors:

Cynthia Burrows - Stony Brook NY
Thomas R. Wagler - Chatham NY
Heungsik Yoon - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07D30103

US Classification:

549520

Abstract:

A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1## wherein: n=0 or 1; m=0 or 1; n+m>0; X. sub. 1, X. sub. 2, Z. sub. 1 and Z. sub. 2 independently represent H. sub. 2 or O; Y. sub. 1, Y. sub. 2, Y. sub. 3 and Y. sub. 4 independently represent H, lower alkyl or CH. sub. 2 COOH; L. sub. 1 and L. sub. 2 independently represent side chains of alpha amino acids, except that L. sub. 1 and L. sub. 2 do not both represent H; and R. sub. 1 and R. sub. 2 independently represent H or OH forms stable complexes with transition metal ions that may be used as catalysts for oxidizing alkenes to epoxides with oxidizing agents. A method is also provided for oxidizing alkenes to epoxides by treating the alkene with a transition metal ion complex which includes the 13 or 14 member macrocyclic compound of the invention, a cyclam or a Schiff base complex and peroxymonosulfate ion or hypochlorite ion in a two phase system comprising a phase transfer catalyst, a water phase having a pH from about 6 to about 14 and an inorganic solvent phase in which the complex is sufficiently soluble.

US Patent:

54281806, Jun 27, 1995

Filed:

Dec 10, 1993

Appl. No.:

8/165063

Inventors:

Cynthia Burrows - Stony Brook NY
Thomas R. Wagler - Chatham NJ
Heungsik Yoon - Stony Brook NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07D30103
C07D30112

US Classification:

549520

Abstract:

A method is provided for oxidizing alkenes to epoxides by treating the alkene with a transition metal ion complex which includes a salen or salophen derivative and peroxymonosulfate ion or hypochlorite ion in a two phase system with a phase transfer catalyst, a water phase having a pH from about 6 to about 12. 9 and an inorganic solvent phase in which the complex is sufficiently soluble.

US Patent:

56101490, Mar 11, 1997

Filed:

May 12, 1995

Appl. No.:

8/439808

Inventors:

Cynthia J. Burrows - Salt Lake City UT
Hsing-Pang Hsieh - Taipei, TW

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

A61K 31575
C07J 900
C07J 4100

US Classification:

514169

Abstract:

New steroidal polyamines have the structure of formula I or formula II: ##STR1## wherein R. sub. 1 and R. sub. 2 are independently N(R'). sub. 3. sup. + or H in the. alpha. - or. beta. - position except both R. sub. 1 and R. sub. 2 are not H; R. sub. 3 is N(R'). sub. 3. sup. + in the. alpha. - position or hydrogen R. sub. 4 is OH, N(R'). sub. 3, or NHC(NH. sub. 2)NH. sub. 2. sup. + R' is hydrogen, alkyl of one to four carbons, aralkyl, or combinations thereof.