Cynthia Diane Gates

US Patent:

58694757, Feb 9, 1999

Filed:

Nov 14, 1997

Appl. No.:

8/970843

Inventors:

Timothy Thomas Curran - Chester NY
Chi-Hsin Richard King - Taipei, TW
Gary Alan Flynn - Tucson AZ
Philip M. Weintraub - Cincinnati OH
Michael R. Angelastro - Mason OH
Cynthia A. Gates - Fairfield OH

Assignee:

Merrell Pharmaceuticals, Inc. - Cincinnati OH

International Classification:

A61K 3156

US Classification:

514177

Abstract:

The invention discloses 3-ketosteroids of the following formula used to inhibit steroid 5. alpha. -reductase: ##STR1## wherein R is OH, C. sub. 1 -C. sub. 6 alkanoyl, C. sub. 1 -C. sub. 6 alkanoyloxy, C. sub. 1 -C. sub. 4 alkanol, COCH. sub. 2 OH, CO. sub. 2 H, CONR. sub. 7 R. sub. 8, cyclopropoxy, acetylthioalkane, cyclopylamino, 2-2-dimethyldioxolan-4-yl, 1,2-dihydroxyethyl and C. sub. 1-4 alkanethiol; R. sub. 1 is hydrogen, hydroxy or C. sub. 1-6 alkyl; R. sub. 1 and R. sub. 2 together may indicate. dbd. O, that is an oxygen double bonded to the 17 carbon; R. sub. 2, R. sub. 3 and R. sub. 4 are each independently hydrogen or C. sub. 1-6 alkyl; R. sub. 5 and R. sub. 6 are each independently hydrogen or OH; R. sub. 5 and R. sub. 6 together may indicate. dbd.