Cynthia S Stevenson

US Patent:

6569406, May 27, 2003

Filed:

Aug 7, 2001

Appl. No.:

09/923519

Inventors:

Cynthia Stevenson - Mountain View CA
Jayne E. Hastedt - San Carlos CA
S. Russ Lehrman - Los Altos CA
David B. Bennett - San Jose CA
David Lesikar - Palo Alto CA
Bing Yang - Redwood City CA
David Gong - San Mateo CA
Kirsten Cabot - San Francisco CA

Assignee:

Nektar Therapeutics - San Carlos CA

International Classification:

A61K 900

US Classification:

424 43, 46489, 12820315, 514 2

Abstract:

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 -helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i. e. , demonstrating superior aerosol performance).

US Patent:

6838075, Jan 4, 2005

Filed:

Mar 14, 2003

Appl. No.:

10/389628

Inventors:

Cynthia Stevenson - Mountain View CA, US
Jayne E. Hastedt - San Carlos CA, US
Russ Lehrman - Los Altos CA, US
David B. Bennett - San Jose CA, US
David Lesikar - Palo Alto CA, US
Bing Yang - Redwood City CA, US
David Gong - San Mateo CA, US
Kirsten Cabot - San Francisco CA, US

Assignee:

Nektar Therapeutics - San Carlos CA

International Classification:

A61K 912
A61K 914

US Classification:

424 43, 424 45, 424489, 514 2, 530300, 12820315

Abstract:

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 α-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i. e. , demonstrating superior aerosol performance).

US Patent:

20050123509, Jun 9, 2005

Filed:

Oct 16, 2002

Appl. No.:

10/493181

Inventors:

S. Lehrman - Los Altos CA, US
Bing Yang - Redwood City CA, US
Cynthia Stevenson - Mountain View CA, US

International Classification:

A61K038/28
B29B009/00
A61K031/727
A61K038/21
A61K039/395

US Classification:

424085200, 514012000, 514056000, 424130100, 264005000, 424085400, 514003000

Abstract:

Methods are provided for preparing spray-dried, drug-containing particles comprising the steps of selecting (i) a drug and an optional excipient, wherein the combination of the drug and optional excipient has an effective pI, and (ii) an aqueous solution having a pH that is different from the effective pI; (b) combining the solution and the drug and optional excipient, wherein an absolute net charge is associated with the drug and optional excipient as a result of an absolute difference between the pH and effective pI; and (c) spray drying the solution to form the spray-dried, drug-containing particles. Particles and compositions comprising the prepared particles as well as methods of use are also provided.

US Patent:

20050186143, Aug 25, 2005

Filed:

Nov 17, 2004

Appl. No.:

10/991344

Inventors:

Cynthia Stevenson - Mountain View CA, US
Jayne Hastedt - San Carlos CA, US
S. Lehrman - Los Altos CA, US
David Bennett - San Jose CA, US
David Lesikar - Palo Alto CA, US
Bing Yang - Redwod City CA, US
David Gong - San Mateo CA, US
Kirsten Cabot - San Francisco CA, US

Assignee:

Nektar Therapeutics - San Carlos CA

International Classification:

A61L009/04
A61K038/21
A61K038/20
A61K038/19
A61K009/14

US Classification:

424046000, 424085100, 424085200, 424085600

Abstract:

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 α-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

US Patent:

60666196, May 23, 2000

Filed:

Apr 16, 1999

Appl. No.:

9/293172

Inventors:

Cynthia L. Stevenson - Mountain View CA
Sally A. Tao - San Jose CA
Steven J. Prestrelski - Mountain View CA
James B. Eckenhoff - Los Altos CA
Jeremy C. Wright - Los Altos CA
John J. Leonard - Cupertino CA

Assignee:

Alza Corporation - Mt. View CA

International Classification:

A61K 3800
C07K 500
C07K 700

US Classification:

514 12

Abstract:

This invention relates to stable non-aqueous protic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous protic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

US Patent:

59325470, Aug 3, 1999

Filed:

Jun 13, 1997

Appl. No.:

8/874233

Inventors:

Cynthia L. Stevenson - Mountain View CA
Steven J. Prestrelski - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61K 3800
C07K 500
C07K 700

US Classification:

514 15

Abstract:

This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non- aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

US Patent:

62357123, May 22, 2001

Filed:

Feb 28, 2000

Appl. No.:

9/514951

Inventors:

Cynthia L. Stevenson - Mountain View CA
Steven J. Prestrelski - Mountain View CA

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61K 3800
C07K 500
C07K 700

US Classification:

514 11

Abstract:

This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

US Patent:

61242616, Sep 26, 2000

Filed:

Apr 19, 1999

Appl. No.:

9/293839

Inventors:

Cynthia L. Stevenson - Mountain View CA
Steven J. Prestrelski - Mountain View CA

Assignee:

ALZA Corporation - Mt. View CA

International Classification:

A61K 3800
A61K 3824
C07K 500
C07K 700

US Classification:

514 12

Abstract:

This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.