Dale H Patterson

US Patent:

6940065, Sep 6, 2005

Filed:

Aug 22, 2003

Appl. No.:

10/646371

Inventors:

Armin Graber - Marlboro MA, US
Dale H. Patterson - Hudson MA, US
Peter Juhasz - Natick MA, US
Stephen A. Martin - Belmont MA, US

Assignee:

Applera Corporation - Norwalk CT

International Classification:

H01J049/00
B01D059/44

US Classification:

250282, 290281, 290287, 290288, 382128, 382129

Abstract:

In various embodiments, the methods for analyzing a sample are provided utilizing a result dependent acquisition strategy. In various embodiments, methods for analyzing a sample are provided wherein the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MALDI and MS/MS or MSto produce a second result.

US Patent:

58692401, Feb 9, 1999

Filed:

May 19, 1995

Appl. No.:

8/447175

Inventors:

Dale H. Patterson - Nashua NH

Assignee:

PerSeptive Biosystems, Inc. - Framingham MA

International Classification:

C12Q 168
G06F 1546
G06G 758
C07K 500

US Classification:

435 6

Abstract:

Integrated methods and apparatus for sequencing or identifying polymers by mass spectrometry with a statistical certainty. The methods involve integrating data obtained by mass spectrometry analysis of a series of polymer fragments and statistically comparing said data with hypothetical data corresponding to known sequences or identities.

US Patent:

58276599, Oct 27, 1998

Filed:

Feb 7, 1997

Appl. No.:

8/796598

Inventors:

Dale H. Patterson - Nashua NH

Assignee:

PerSeptive Biosystems, Inc. - Framingham MA

International Classification:

C12Q 168
C12Q 170
C12P 1934
C07K 500

US Classification:

435 6

Abstract:

The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. The methods further involve integrating data obtained from mass spectrometry analysis of a plurality of series of hydrolyzed polymer fragments, and optionally provide statistical interpretation paradigms and computer software therefor. The apparatus involves a mass spectrometer sample holder, having hydrolyzing agent disposed thereon, which is useful for adapting any mass spectrometer for polymer sequencing.

US Patent:

58210636, Oct 13, 1998

Filed:

Apr 18, 1997

Appl. No.:

8/844462

Inventors:

Dale H. Patterson - Nashua NH
George E. Tarr - S. Hamilton MA

Assignee:

PerSeptive Biosystems, Inc. - Framingham MA

International Classification:

C12Q 168
C12Q 134
C12N 914
C12N 924

US Classification:

435 6

Abstract:

The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. The methods further involve integrating data obtained from mass spectrometry analysis of a plurality of series of hydrolyzed polymer fragments, and optionally provide statistical interpretation paradigms and computer software therefor. The apparatus involves a mass spectrometer sample holder, having hydrolyzing agent disposed thereon, which is useful for adapting any mass spectrometer for polymer sequencing.