Dale Robert Pfost

US Patent:

6485690, Nov 26, 2002

Filed:

May 27, 1999

Appl. No.:

09/321410

Inventors:

Dale R. Pfost - Pennington NJ
Sheila H. DeWitt - Stockton NJ
Chao Lin - Monmouth Junction NJ
Rolf E. Swenson - Princeton NJ
Robert D. Juncosa - Yardley PA
Gary J. Schnerr - Pennington NJ
Sheldon M. Kugelmass - New York NY

Assignee:

Orchid BioSciences, Inc. - Princeton NJ

International Classification:

B01L 300

US Classification:

422102, 422 681, 422 99, 422100, 436174, 436179, 436180

Abstract:

Multiple fluid sample processors and systems for high throughput chemical synthesis and biological assays and/or processing. A multi-layered fluidic array having microchannels, reservoirs and reaction wells is subject to robotic and automated handling. A pressure pumping system is utilized for fluid delivery and control through the synthesis process. The sizes of the micro-sized channels, apertures, and valves are adjusted to optimize fluid distribution and channel filling. The fluid sample processors can be grouped together in a microtiter format to increase the speed, quantity and efficiency of the processing.

US Patent:

6534321, Mar 18, 2003

Filed:

Jan 8, 1999

Appl. No.:

09/227446

Inventors:

Rajesh Bhikhu Parekh - Near Wendlebury, GB
Paul Nicholas Goulding - Cambridgeshire, GB
Dale Robert Pfost - Pennington NJ

Assignee:

Oxford GlycoSciences (UK) Ltd. - Abingdon

International Classification:

G01N 33543

US Classification:

436514, 204450, 204456, 204465, 204466, 204600, 422 50, 435968, 436516, 436528

Abstract:

A method for analyzing a sample containing a plurality of analytes, comprises labelling the analytes with a detectable label, the label being chosen such that its detectability can be influenced by modifying the conditions of detection; separating the labelled analytes, before or after labeling,; and determining the presence of the separated analytes under the modified conditions and also, if desired, the unmodified conditions. Suitable detection apparatus comprises a support for a gel, means for detecting one or more analytes in the gel, and means for reducing the temperature of the gel to below ambient temperature, e. g. , to no more than 0ÂC.

US Patent:

20020156043, Oct 24, 2002

Filed:

Dec 27, 2001

Appl. No.:

10/034882

Inventors:

Dale Pfost - Pennington NJ, US

Assignee:

ORCHID BIOSCIENCES, INC.

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

Provided are compositions of compounds effective for treating a pathology, the composition comprising at least two compounds that modulate the activity of one or more target molecules associated with one or more Single Nucleotide Polymorphisms (SNPs). Methods are also provided for increasing overall treatment efficacy for a population of patients having a pathology.

US Patent:

20040176315, Sep 9, 2004

Filed:

Mar 9, 2004

Appl. No.:

10/797164

Inventors:

Dale Pfost - Pennington NJ, US

Assignee:

ORCHID BIOSCIENCES, INC.

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

Provided are compositions of compounds effective for treating a pathology, the composition comprising at least two compounds that modulate the activity of one or more target molecules associated with one or more Single Nucleotide Polymorphisms (SNPs). Methods are also provided for increasing overall treatment efficacy for a population of patients having a pathology.

US Patent:

45233195, Jun 11, 1985

Filed:

May 10, 1983

Appl. No.:

6/493149

Inventors:

Dale R. Pfost - Los Altos CA

Assignee:

Brown University - Providence RI

International Classification:

H01S 306

US Classification:

372 54

Abstract:

A laser tape system for use in the resonant cavity of laser consisting of a flexible tape carrying at least one lasing dye and adapted for insertion into the resonant cavity, and a drive mechanism for moving the tape such that different portions of the tape may be focused within the cavity.

US Patent:

51046210, Apr 14, 1992

Filed:

Jul 20, 1989

Appl. No.:

7/383299

Inventors:

Dale R. Pfost - Los Altos CA
Torleif O. Bjornson - Milpitas CA
Robert M. Coppock - Mountain View CA
Carl Kowalski - Fremont CA
Samuel A. Marquiss - Milpitas CA
Donald S. Murray - Sunnyvale CA
R. Fred Pfost - Los Altos CA
Brian Sanford - Cupertino CA
Katherine L. Puckett - Cambridge MA

Assignee:

Beckman Instruments, Inc. - Fullerton CA

International Classification:

G01N 3300

US Classification:

422 67

Abstract:

An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions. The work station is capable of measuring physical characteristics of selected samples and performing experimental assays in a closed loop manner in accordance with those measurements.

US Patent:

53695666, Nov 29, 1994

Filed:

Dec 3, 1992

Appl. No.:

7/985062

Inventors:

Dale R. Pfost - Los Altos CA
Robert M. Coppock - Mountain View CA
Donald S. Murray - Sunnyvale CA
R. Fred Pfost - Los Altos CA
Brian Sanford - Cupertino CA
Katherine L. Puckett - Cambridge MA

Assignee:

Beckman Instruments, Inc. - Fullerton CA

International Classification:

G06F 1546

US Classification:

364147

Abstract:

A method of programming a programmable controller in a manner by which a variety of menus, options, or questions seeking limited parameter answers are presented to the user; for example, setup parameters such as the type of labware, source and destination of reagent transfer etc. for conducting a particular biological and chemical assay experiments by an automated laboratory workstation. Software "templates" are used to focus the request for parameters from the user to tailor user needs to the laboratory workstation's capabilities. The software templates are designed to accommodate a wide variety of experimental setups in accordance with the setup parameters input by the user. By providing the parameters with the assistance of the templates, the user may program a complete set of instructions for conducting a biological or chemical assay. The instructions may include the time and method for undertaking the experiment. Further instructions may be given the laboratory workstation to conduct the later phases of experiments based upon earlier results of measurements.

US Patent:

51087030, Apr 28, 1992

Filed:

May 10, 1991

Appl. No.:

7/698649

Inventors:

Dale R. Pfost - Los Altos CA
Torleif O. Bjornson - Milpitas CA
Robert M. Coppock - Mountain View CA
Carl Kowalski - Fremont CA
Samuel A. Marquiss - Milpitas CA
Donald S. Murray - Sunnyvale CA
R. Fred Pfost - Los Altos CA
Brian Sanford - Cupertino CA
Katherine L. Puckett - Cambridge MA

Assignee:

Beckman Instruments, Inc. - Fullerton CA

International Classification:

G01N 3300

US Classification:

422 65

Abstract:

An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The work station combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions. The work station is capable of measuring physical characteristics of selected samples and performing experimental assays in a closed loop manner in accordance with those measurements.