Dalia El-Sherif

US Patent:

7897141, Mar 1, 2011

Filed:

Apr 1, 2002

Appl. No.:

10/472430

Inventors:

Margaret A. Wheatley - Media PA, US
Dalia El-Sherif - King of Prussia PA, US

Assignee:

Drexel University - Philadelphia PA

International Classification:

A61B 8/00

US Classification:

424 95, 424 952

Abstract:

Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided.

US Patent:

20030143280, Jul 31, 2003

Filed:

Jan 31, 2003

Appl. No.:

10/355772

Inventors:

Dalia El-Sherif - Penn Valley PA, US
Jeylan El-Mansoury - Penn Valley PA, US

International Classification:

A61K031/717
A61K009/16
A61K009/50

US Classification:

424/490000, 514/057000, 514/059000

Abstract:

A treatment for dry eye and other eye problems using a plug system or a delivery system. The plug system comprises solid, porous or hollow microcapsules composed of a biodegradable biocompatible polymer. The capsules are stored in the form of a powder that can be suspended in an aqueous carrier solution or dispersed in a gel or an ointment. Alternatively a biodegradable biocompatible capsule having a treating agent encapsulated within a polymer shell or a polymer sphere, again stored in the form of a powder that can be suspended in an aqueous carrier solution or dispersed in a gel or an ointment. The plug system prevents excretion of the capsules and their size is larger then the punctum and to prevent entrance to the lachrymal excretory system. The treatment is slowly released into the eye through the polymer shell or sphere and/or gets secreted as the polymer degrades.

US Patent:

20040258761, Dec 23, 2004

Filed:

Mar 22, 2004

Appl. No.:

10/805704

Inventors:

Margaret Wheatley - Media PA, US
Nikhil Dhoot - Cortland Manor NY, US
Justin Lathia - Elizabethtown PA, US
Dalia El-Sherif - King of Prussia PA, US

International Classification:

A61K009/16
A61K009/50

US Classification:

424/490000, 264/004100

Abstract:

Methods for producing polymer-based microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided. Methods for enhancing delivery of nanocapsules via ultrasound are also provided.

US Patent:

20050158362, Jul 21, 2005

Filed:

Jun 25, 2001

Appl. No.:

10/312189

Inventors:

Margaret Wheatley - Media PA, US
Frank Ko - Philadelphia PA, US
Dalia El-Sherif - King of Prussia PA, US
Nikhil Dhoot - Philadelphia PA, US
Saravanan Kanakasabai - King of Prussia PA, US
Meriem Benjelloun - Philadelphia PA, US
Baohua Han - Lake Hiawatha NJ, US

International Classification:

A61F002/00

US Classification:

424426000, 427002210

Abstract:

Multifunctional systems for delivery of bioactive compounds incorporated within or between polymeric fibers in a matrix are provided. Also provided are methods of delivering bioactive compounds via implementation, coating and/or wrapping of these systems and methods for modulating the rate of release of bioactive compounds from these delivery systems.

US Patent:

20090196827, Aug 6, 2009

Filed:

May 21, 2007

Appl. No.:

12/301423

Inventors:

Margaret A. Wheatley - Media PA, US
Odelia Mualem Burstein - Philadelphia PA, US
John R. Eisenbrey - Middletown DE, US
Dalia El-Sherif - King of Prussia PA, US

Assignee:

Drexel University - Philadelphia PA

International Classification:

A61K 49/22
A61K 9/50
A61K 9/51
B29B 9/00

US Classification:

424 95, 424490, 424489, 264 5, 977906, 977929

Abstract:

This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the method of the invention wherein the echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof contain at least 10% more of a drug as compared to (1) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug prior to emulsifying or (2) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug to lyophilized polymer microcapsules, nanocapsules, or mixtures thereof.

US Patent:

20110125079, May 26, 2011

Filed:

Jan 31, 2011

Appl. No.:

13/017345

Inventors:

Margaret A. Wheatley - Media PA, US
Dalia El-Sherif - King of Prussia PA, US

International Classification:

A61M 37/00
A61K 49/22
A61K 9/50
A61K 9/51
B82Y 5/00

US Classification:

604 20, 424 95, 424463, 977788, 977832, 977929

Abstract:

Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided.

US Patent:

20140213702, Jul 31, 2014

Filed:

Apr 2, 2014

Appl. No.:

14/243192

Inventors:

- Philadelphia PA, US
Dalia El-Sherif - King of Prussia PA, US

Assignee:

DREXEL UNIVERSITY - Philadelphia PA

International Classification:

C08L 67/04
C08L 29/04

US Classification:

524 91, 524360

Abstract:

One aspect of the invention provides a precursor to an echogenic polymer microcapsule or nanocapsule. The precursor includes an emulsion including a polymer solution and an aqueous solution including a water-soluble sublimable solute. This aspect of the invention can have a variety of embodiments. In one embodiment, the water-soluble sublimable solute can be an ammonium salt. For example, the ammonium salt can be ammonium carbonate.