Daniel Yen Chu

US Patent:

6503737, Jan 7, 2003

Filed:

Oct 1, 1999

Appl. No.:

09/410551

Inventors:

Christopher Reeves - Orinda CA
Daniel Chu - Santa Clara CA
Chaitan Khosla - Palo Alto CA
Daniel Santi - San Francisco CA
Kai Wu - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P 1962

US Classification:

435 76, 4353201, 4352523, 43525235, 536 231, 536 232

Abstract:

Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

US Patent:

6569867, May 27, 2003

Filed:

May 10, 2001

Appl. No.:

09/853306

Inventors:

Daniel Chu - Santa Clara CA
Maria Fardis - San Carlos CA
Chaitan Khosla - Palo Alto CA
Christopher Reeves - Orinda CA
Daniel Santi - San Francisco CA
Andreas Schirmer - Hayward CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D49816

US Classification:

514291, 540456

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a âmacrolidesâ or âmacrolactonesâ) that include as part of their structure and bind to a FK binding protein wherein R and R are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R and R is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

US Patent:

6593302, Jul 15, 2003

Filed:

Feb 13, 2002

Appl. No.:

10/075466

Inventors:

Daniel Chu - Santa Clara CA
Gary Ashley - Alameda CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

A61K 3170

US Classification:

514 29, 536 72, 536 74

Abstract:

Compounds of the formula wherein R is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or OR is replaced by H; R is H or halogen; R is H or a protecting group; R is methyl, unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); R is H or a protecting group; L is methylene or carbonyl; T is âOâ, âN(R)â, âN(OR)â, âN(NHCOR)â, âN(N CHR)â, or âN(NHR)â wherein R is H or R as defined above, with the proviso that when L is methylene, T is âOâ; one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or Z and Y together are O, NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.

US Patent:

6624302, Sep 23, 2003

Filed:

Dec 27, 2002

Appl. No.:

10/331047

Inventors:

Daniel Chu - Santa Clara CA
Maria Fardis - San Carlos CA
Chaitan Khosla - Palo Alto CA
Christopher Reeves - Orinda CA
Daniel Santi - San Francisco CA
Andreas Schirmer - Hayward CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D49816

US Classification:

540456

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a âmacrolidesâ or âmacrolactonesâ) that include as part of their structure and bind to a FK binding protein wherein R and R are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R and R is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

US Patent:

6638927, Oct 28, 2003

Filed:

Aug 31, 2001

Appl. No.:

09/945384

Inventors:

Paul A. Renhowe - Danville CA
Daniel Chu - Santa Clara CA
Rustum S. Boyce - San Francisco CA
Zhi-Jie Ni - Fremont CA
David Duhl - Oakland CA
Effie Tozzo - Newton MA
Kirk Johnson - Moraga CA
David C. Myles - Kensington CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C07D29520

US Classification:

514218, 544400, 544374, 51425212, 5142541, 540575, 564163, 564164

Abstract:

Compounds of formula IA and IB are new where the variables R through R have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.

US Patent:

6660862, Dec 9, 2003

Filed:

Apr 3, 2001

Appl. No.:

09/825621

Inventors:

Christopher Reeves - Orinda CA
Daniel Chu - Santa Clara CA
Chaitan Khosla - Palo Alto CA
Daniel Santi - San Francisco CA
Kai Wu - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D51500

US Classification:

546 92

Abstract:

Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.

US Patent:

6716840, Apr 6, 2004

Filed:

Apr 8, 2002

Appl. No.:

10/118730

Inventors:

Daniel Chu - Santa Clara CA
Rustum S. Boyce - San Francisco CA
David Duhl - Oakland CA
Bryan H. Chang - Concord CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

A61K 315375

US Classification:

5142335, 544144, 544373, 546201, 548465, 51425401

Abstract:

Compounds having the general structure I are provided: X and Y are independently selected from the group consisting of CH , N, NR , C O, C S, S O, SO , S, O, (CR R ) , C( O)â(CR R ) , and C( S)â(CR R ) , where n is 1, 2, or 3. W is selected from the group consisting of and L is selected from the group consisting of N, O, S, S O, SO , C(O), NC(O), NC(S), OC(O), OC(S), C(NR ), C(NOR ), and a covalent bond. Z , Z , and Z are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (âMC-4râ) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.

US Patent:

6756359, Jun 29, 2004

Filed:

Jul 3, 2002

Appl. No.:

10/190431

Inventors:

Daniel Chu - Santa Clara CA
Matthew Burger - Albany CA
Xiaodong Lin - Walnut Creek CA
Georgia Law Carroll - Walnut Creek CA
Jacob Plattner - Berkeley CA
Alice Rico - Berkeley CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

A61K 3170

US Classification:

514 29, 536 72, 536 73, 536 74

Abstract:

Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.