Daniel Fologea

US Patent:

20120041357, Feb 16, 2012

Filed:

Mar 31, 2010

Appl. No.:

13/259650

Inventors:

Daniel Fologea - Boise ID, US
Greg Salamo - Fayetteville AR, US
Ralph Henry - Fayetteville AR, US
Michael J. Borrelli - Little Rock AR, US
Peter M. Corry - Little Rock AR, US

Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS - Little Rock AR

International Classification:

A61M 37/00
A61K 38/54
A61P 35/00
A61K 49/00
A61K 38/46
A61K 38/48
A61K 9/127
A61K 51/12

US Classification:

604 20, 424450, 424 943, 424 121, 424 91, 424 946, 424 9463

Abstract:

Disclosed are methods and compositions for the controlled release of a drug or agent from a liposome using light or radiation. Also disclosed are compositions comprising liposomes having a lipid layer, wherein the liposomes contain an agent, an enzyme capable of releasing the agent from the liposome, and an enzyme activator sequestered by a molecular cage. In another aspect, methods of delivering an agent to a target in a subject are disclosed.

US Patent:

20200405857, Dec 31, 2020

Filed:

Feb 18, 2019

Appl. No.:

16/971158

Inventors:

- Boise ID, US
Daniel FOLOGEA - Boise ID, US

International Classification:

A61K 41/00
A61K 9/127
A61K 38/17
A61K 38/16
A61N 5/06

Abstract:

The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.

US Patent:

20190388559, Dec 26, 2019

Filed:

Jun 25, 2019

Appl. No.:

16/451967

Inventors:

- Boise ID, US
Daniel Fologea - Boise ID, US
Catherine Anders - Boise ID, US
Denise Wingett - Boise ID, US

International Classification:

A61K 47/69
A61K 9/50
A61K 9/48
A61K 8/11
A61K 9/51
A61K 9/127
A61K 47/02

Abstract:

The present invention is directed to micro and nanosized capsule compositions and methods of using and making the capsule compositions. The capsule compositions comprise an outer layer of lipids and/or polymers and inner contents comprising semiconductor nanoparticles. The nanoparticles are either metal oxides or quantum dots and will produce reactive oxygen species when irradiated with either electromagnetic radiation or ultrasound. The reactive oxygen species will degrade the outer layer of the capsule and cause the release of the contents, including the reactive oxygen species, into the local environment. The contents may optionally include cancer treating agent, water treating agents, antimicrobials, imaging and/or contracting agents. The outer layer may be further coated to protect it from environmental factors and/or be conjugated with a targeting molecule to increase delivery to a target.