John A. MCCAULEY - West Point PA, US David Johathan BENNETT - Boston MA, US Christopher J. BUNGARD - West Point PA, US Thomas J. GRESHOCK - West Point PA, US M. Katharine HOLLOWAY - West Point PA, US Peter D. WILLIAMS - Harleysville PA, US Christian BEAULIEU - Laval, Quebec, CA Sheldon CRANE - Ile Perrot, Quebec, CA Stephanie LESSARD - St-Jean-sur-Richelieu, QC, CA Daniel MCKAY - Milton MA, US Carmela MOLINARO - Rahway NJ, US Oscar Miguel MORADEI - Burlington MA, US Vijayasaradhi SIVALENKA - Singapore, SG Vouy Linh TRUONG - Pierrefonds, QC, CA Satyanarayana TUMMANAPALLI - Singapore, SG - Kirklan, CA
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z, Z, V, V, V, R, R, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HV protease, the inhibition of HV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
JOHN A. MCCAULEY - MAPLE GLEN PA, US CHRISTIAN BEAULIEU - LAVAL, CA DAVID J. BENNETT - NEW HOPE PA, US CHRISTOPHER J. BUNGARD - LANSDALE PA, US RONALD K. CHANG - ORELAND PA, US SHELDON CRANE - ILE PERROT, CA THOMAS J. GRESHOCK - COLLEGEVILLE PA, US LI HAO - SINGAPORE, SG KATE HOLLOWAY - LANSDALE PA, US JESSE J. MANIKOWSKI - NORRISTOWN PA, US DANIEL MCKAY - MILTON MA, US CARMELA MOLINARO - WEST POINT PA, US OSCAR MIGUEL MORADEI - KIRKLAND, CA PHILIPPE G. NANTERMET - LANSDALE PA, US CHRISTIAN NADEAU - MONTREAL, CA TUMMANAPALLI SATYANARAYANA - SINGAPORE, SG WILLIAM SHIPE - CHALFONT PA, US SANJAY KUMAR SINGH - SINGAPORE, SG VOUY LINH TRUONG - PIERREFONDS, CA SIVALENKA VIJAYARADHI - SINGAPORE, SG PETER D. WILLIAMS - HARLEYSVILLE PA, US CATHERINE M. WISCOUNT - ALLENTOWN PA, US
The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Name / Title
Company / Classification
Phones & Addresses
Daniel Mckay
MCKAY'S CUSTOM BUILDING & CONTRACTING, LLC
Daniel W. Mckay
COSHOCTON PROJECT LLC
Daniel Mckay Vice-President
The Camera Shop Inc Ret Cameras/Photography Supplies
485 Park Way, Marple Township, PA 19008 (610)3285700
Visual Sound
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Avhq 1997 - 2000
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Education:
Temple University 1979 - 1984
Associates, Associate of Arts, Engineering
Skills:
Av Video Conferencing Crestron Digital Signage Audio Conferencing Telepresence Video Extron Tandberg Streaming Media Sound Troubleshooting Audio Engineering Professional Audio Unified Communications
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Villanova University 2004 - 2008
Bachelors, Bachelor of Business Administration, Marketing, International Business
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Pharmacovigilance Associate / Team Leader
Health and Safety Executive Jan 2002 - Apr 2005
Regulatory Scientist
Education:
University of Hertfordshire 2006 - 2010
PgDip, Pharmacovigilance
University of Liverpool 1996 - 1999
BSc (Hons), Pharmacology
Skills:
Pharmacovigilance Regulatory Affairs Pharmaceutical Industry Drug Safety Lifesciences Medical Devices Regulatory Requirements Pharmacology ISO 13485 CAPA
Aug 2005 to 2000 Executive Technology SupportBank of America
Jul 2003 to Aug 2005 Level III Development Application Desktop SupportIBM Charlotte, NC May 1999 to Jul 2003 Technical Team leader / HelpdeskT-Shirt City
Aug 1998 to May 1999 California Shirt SalesMobile Paper Shredding/Recycling Co Charlotte, NC Mar 1998 to Aug 1998 Outside Sales RepresentativeUltra Air Products, Inc Charlotte, NC Nov 1996 to Mar 1998 Southeastern Regional Sales ExecutiveUnited States Military (Army) Fort Bragg, NC Nov 1992 to Nov 1996 Infantryman / Paratrooper
Education:
Central Piedmont Community College Charlotte, NC Dec 2000 A.A.S. in Information Systems / Network Administration and SupportAMX University Baltimore, MD Cisco Networking Academy Program Charlotte, NC