Daniel W Mckay

US Patent:

20110237622, Sep 29, 2011

Filed:

Dec 8, 2009

Appl. No.:

13/139012

Inventors:

Austin Chih-Yu Chen - San Diego CA, US
Daniel Dube - St. Lazare, CA
Pierre-Andre Fournier - Laval, CA
Erich L. Grimm - Baie d'Urfe, CA
Patrick Lacombe - Montreal, CA
Sebastien Laliberte - St. Lazare, CA
Dwight Macdonald - L'Ile Bizard, CA
D. Bruce Mackay - Dollard-des-Ormeaux, CA
Daniel James Mckay - Lexington MA, US
Tom Yao-Hsiang Wu - San Diego CA, US

Assignee:

Merck Frosst Canada LTD. - Kirkland

International Classification:

A61K 31/4545
C07D 401/04
A61P 9/12
A61P 9/00
A61P 9/10
A61P 13/12
A61P 11/00
A61P 25/22
A61P 25/00
A61P 15/10
A61P 27/06

US Classification:

514318, 546194

Abstract:

The present invention relates to 3,4-substituted piperidinyl—based renin inhibitor compounds bearing at 4-position oxopyridine or Isoquinolone and having the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

US Patent:

20120046293, Feb 23, 2012

Filed:

Oct 10, 2011

Appl. No.:

13/269882

Inventors:

CHRISTOPHER I. BAYLY - Beaconsfield, CA
Austin C. Chen - San Diego CA, US
Daniel Dube - St. Lazare, CA
Laurence Dube - Laval, CA
Michel Gallant - Kirkland, CA
Patrick Lacombe - Montreal, CA
Dwight MacDonald - L'lle Bizard, CA
Daniel McKay - Milton MA, US
David A. Powell - Lansdale PA, US
Erich L. Grimm - Baie d'Urfe, CA

Assignee:

Merck Frosst Canada Ltd. - Kirkland

International Classification:

A61K 31/165
C07D 295/192
A61K 31/5375
A61K 31/196
A61K 31/216
C07D 213/56
A61K 31/4425
A61K 31/4402
C07C 271/48
A61K 31/27
A61K 31/495
C07D 295/205
C07C 237/20
A61P 9/12
A61P 9/00
A61P 9/10
A61P 27/06
A61P 25/00
A61P 25/22
A61P 15/10
C07C 235/36

US Classification:

5142375, 564174, 514622, 564161, 544176, 562455, 514563, 560 45, 514531, 546337, 514357, 560160, 514506, 544389, 51425501, 544171, 564165, 514620

Abstract:

The present invention relates to renin inhibitor compounds having the structureand their use in treating cardiovascular events and renal insufficiency.

US Patent:

20120190701, Jul 26, 2012

Filed:

Aug 17, 2010

Appl. No.:

13/390465

Inventors:

Austin Chih-Yu Chen - San Marcos CA, US
Sebastien Laliberte - Saint-Lazare, CA
Guillaume Larouche - St-Jean sur Richelieu, CA
Yongxin Han - Montreal, CA
Daniel McKay - Milton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/438
C07D 491/20
A61K 31/4709
A61K 31/4725
A61P 9/12
A61P 25/22
A61P 9/00
A61P 9/10
A61P 13/12
A61P 25/00
A61P 27/02
A61P 27/06
C07D 491/107
A61P 9/04

US Classification:

514278, 546 17

Abstract:

Renin inhibitors, which are spirocyclic piperidine amides, of structural formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency. wherein n, for each instance in which it occurs, is independently 0, 1, or 2; Ris hydrogen, C-alkyl or C-cycloalkyl, wherein said C-alkyl or C-cycloalkyl group can be independently substituted with 1-3 halogens; A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to another five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is a bond or —(C═O)—, —CH(OH)—, —CH—or ═CH—; U is a bond or —CH2-, or for the case when V is ═CH—, U is —CH═; X is ═CH—, ═CF—, ═C(OR)—, or —C═O—; and Y is ═CH—, ═CF—, ═N—, or for the case when X is —C═O—, Y is —N(R)—.