Daniel D Ortuno

age ~58

from San Marcos, CA

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Daniel Ortuno Phones & Addresses

Endogenous And Non-Endogenous Versions Of Human G Protein-Coupled Receptors
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US Patent:

20060240523, Oct 26, 2006
Filed:

Jun 30, 2006
Appl. No.:

11/479174
Inventors:

Chen Liaw - San Diego CA, US
Derek Chalmers - Cardiff CA, US
Dominic Behan - San Diego CA, US
James Leonard - San Diego CA, US
I-Lin Lin - San Diego CA, US
Daniel Ortuno - Vista CA, US
Assignee:

Arena Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07K 14/705
C07H 21/04
C12P 21/06
US Classification:

435069100, 435320100, 435325000, 530350000, 536023500
Abstract:

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.

Methods For Producing Olfactory Gpcrs
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US Patent:

20080009015, Jan 10, 2008
Filed:

Nov 15, 2004
Appl. No.:

10/579399
Inventors:

Gene Hung - San Diego CA, US
Daniel Ortuno - Vista CA, US
David Unett - San Diego CA, US
Joel Gatlin - San Diego CA, US
Assignee:

Arena Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07K 14/705
G01N 33/53
C12P 21/06
US Classification:

435007100, 435368000, 435069100, 530350000
Abstract:

The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

Methods For Producing Olfactory Gpcrs
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US Patent:

20090280487, Nov 12, 2009
Filed:

Oct 22, 2008
Appl. No.:

12/256311
Inventors:

GENE HUNG - San Diego CA, US
Daniel Ortuno - Acton MA, US
David J. Unett - San Diego CA, US
Joel Gatlin - San Diego CA, US
International Classification:

C12Q 1/68
C12P 21/02
C12Q 1/02
G01N 33/567
C12N 5/10
US Classification:

435 6, 435 691, 435 29, 435 721, 435325
Abstract:

The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

Methods For Producing Olfactory Gpcrs
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US Patent:

20110177522, Jul 21, 2011
Filed:

Aug 20, 2010
Appl. No.:

12/860621
Inventors:

GENE HUNG - SAN DIEGO CA, US
DANIEL ORTUNO - ACTON MA, US
DAVID J. UNETT - SAN DIEGO CA, US
JOEL GATLIN - SAN DIEGO CA, US
International Classification:

G01N 33/53
C12P 21/06
C12Q 1/02
C12N 5/00
US Classification:

435 71, 435 691, 435 29, 435325
Abstract:

The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

Endogenous And Non-Endogenous Versions Of Human G Protein-Coupled Receptors
view source
US Patent:

20030023069, Jan 30, 2003
Filed:

Feb 26, 2002
Appl. No.:

10/083168
Inventors:

Chen Liaw - San Diego CA, US
Derek Chalmers - Cardiff CA, US
Dominic Behan - San Diego CA, US
James Leonard - San Diego CA, US
I-Lin Lin - San Diego CA, US
Daniel Ortuno - Vista CA, US
International Classification:

C07H021/04
C12P021/02
C12N005/06
C07K014/705
US Classification:

536/023500, 530/350000, 435/069100, 435/325000, 435/320100
Abstract:

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.