Daniel E Tracey

US Patent:

6914128, Jul 5, 2005

Filed:

Mar 24, 2000

Appl. No.:

09/534717

Inventors:

Jochen Salfeld - North Grafton MA, US
Michael Roguska - Ashland MA, US
Michael Paskind - Sterling MA, US
Subhashis Banerjee - Shrewsbury MA, US
Daniel Tracey - Harvard MA, US
Michael White - Framingham MA, US
Zehra Kaymakcalan - Westborough MA, US
Boris Labkovsky - Marlborough MA, US
Paul Sakorafas - Newton MA, US
Geertruida M. Veldman - Sudbury MA, US
Amy Venturini - Lexington MA, US
Angela Widom - Acton MA, US
Stuart Friedrich - Melrose MA, US
Nicholas W. Warne - Andover MA, US
Angela Myles - Andover MA, US
John Gawain Elvin - Cambridge, GB
Alexander Robert Duncan - Little Shelford, GB
Elaine Joy Derbyshire - Royston, GB
Sara Carmen - Cambridge, GB
Thor Las Holtet - Royston, GB
Sarah Leila Du Fou - Hitchen, GB
Stephen Smith - Ely, GB

Assignee:

Abbott GmbH & Co. KG - Wiesbaden

International Classification:

C07K016/18
C07K016/24
C12P021/08

US Classification:

5303873, 5303871, 5303879, 53038815, 53038824, 5303892, 530351

Abstract:

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e. g. , in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

US Patent:

7504485, Mar 17, 2009

Filed:

Jul 1, 2004

Appl. No.:

10/884830

Inventors:

Jochen G. Salfeld - North Grafton MA, US
Michael Roguska - Ashland MA, US
Michael Paskind - Sterling MA, US
Subhashis Banerjee - Shrewsbury MA, US
Daniel Edward Tracey - Harvard MA, US
Michael White - Framingham MA, US
Zehra Kaymakcalan - Westborough MA, US
Boris Labkovsky - Marlborough MA, US
Paul Sakorafas - Newton MA, US
Geertruida M. Veldman - Sudbury MA, US
Amy Venturini - Lexington MA, US
Angela Widom - Acton MA, US
Stuart Friedrich - Cary NC, US
Nicholas W. Warne - Andover MA, US
Angela Myles - Andover MA, US
John Gawain Elvin - Cambridge, GB
Alexander Robert Duncan - Cambridge, GB
Elaine J. Derbyshire - Royston, GB
Sara Carmen - Cambridge, GB
Stephen Smith - Ely, GB
Thor Las Holtet - Royston, GB
Sarah Leila Du Fou - Hitchen, GB

Assignee:

Abbott GmbH & Co., KG - Wiesbaden

International Classification:

C07K 16/24
A61K 39/395

US Classification:

53038823, 4241451

Abstract:

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e. g. , in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

US Patent:

7883704, Feb 8, 2011

Filed:

Dec 22, 2006

Appl. No.:

11/645287

Inventors:

Jochen G. Salfeld - North Grafton MA, US
Michael Roguska - Ashland MA, US
Michael Paskind - Sterling MA, US
Subhashis Banerjee - Hamden CT, US
Daniel Edward Tracey - Harvard MA, US
Michael White - Framingham MA, US
Zehra Kaymakcalan - Westborough MA, US
Boris Labkovsky - Marlborough MA, US
Paul Sakorafas - Newton Highlands MA, US
Geertruida M. Veldman - Sudbury MA, US
Amy Venturini - Lexington MA, US
Angela Widom - Acton MA, US
Stuart Friedrich - Cary NC, US
Nicholas W. Warne - Andover MA, US
Angela Kantor - Pepperell MA, US
John Gawain Elvin - Meldreth, GB
Alexander Robert Duncan - Carton, GB
Elaine Joy Derbyshire - Crowthorne, GB
Sara Carmen - Cambridge, GB
Stephen Smith - Ely, GB
Thor Las Holtet - Rønde, DK
Sarah Leila Du Fou - Hitchen, GB

Assignee:

Abbott GmbH & Co. KG - Wiesbaden

International Classification:

A61K 38/20
A61K 39/395
C07K 16/24
C12P 21/08

US Classification:

4241451, 53038823, 5303881, 5303891, 514 14, 4241301

Abstract:

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e. g. , in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

US Patent:

20040126372, Jul 1, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/622932

Inventors:

Subhashis Banerjee - Shrewsbury MA, US
Lori Taylor - Wadsworth IL, US
Clive Spiegler - Reading, GB
Daniel Tracey - Harvard MA, US
Elliot Chartash - Randolph NJ, US
Rebecca Hoffman - Wilmette IL, US
William Barchuk - Madison NJ, US
Philip Yan - Vernon Hills IL, US
Anwar Murtaza - Westborough MA, US
Jochen Salfeld - North Grafton MA, US
Steven Fischkoff - Short Hills NJ, US

Assignee:

Abbott Biotechnology Ltd. - Hamilton

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

Methods of treating TNF-related disorders comprising administering TNF inhibitors, including TNF antibodies are described.

US Patent:

20040126373, Jul 1, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/623065

Inventors:

Subhashis Banerjee - Shrewsbury MA, US
Lori Taylor - Wadsworth IL, US
Clive Spiegler - Reading, GB
Daniel Tracey - Harvard MA, US
Elliot Chartash - Randolph NJ, US
Rebecca Hoffman - Wilmette IL, US
William Barchuk - Madison NJ, US
Philip Yan - Vernon Hills IL, US
Anwar Murtaza - Westborough MA, US
Jochen Salfeld - North Grafton MA, US
Steven Fischkoff - Short Hills NJ, US

Assignee:

Abbott Biotechnology Ltd. - Hamilton

International Classification:

A61K039/395
C12Q001/68

US Classification:

424/145100

Abstract:

Methods for treating coronary disease in which TNF activity is detrimental are described.

US Patent:

20040131614, Jul 8, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/623076

Inventors:

Subhashis Banerjee - Shrewsbury MA, US
Lori Taylor - Wadsworth IL, US
Clive Spiegler - Reading, GB
Daniel Tracey - Harvard MA, US
Elliot Chartash - Randolph NJ, US
Rebecca Hoffman - Wilmette IL, US
William Barchuk - Madison NJ, US
Philip Yan - Vernon Hills IL, US
Anwar Murtaza - Westborough MA, US
Jochen Salfeld - North Grafton MA, US
Steven Fischkoff - Short Hills NJ, US

Assignee:

Abbott Biotechnology Ltd. - Hamilton

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

Methods of treating pulmonary disorders comprising administering TNF inhibitors, including TNF antibodies are described.

US Patent:

20040136989, Jul 15, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/622210

Inventors:

Subhashis Banerjee - Shrewsbury MA, US
Lori Taylor - Wadsworth IL, US
Clive Spiegler - , US
Daniel Tracey - Harvard MA, US
Elliot Chartash - Randolph NJ, US
Rebecca Hoffman - Wilmette IL, US
William Barchuk - Madison NJ, US
Philip Yan - Vernon Hills IL, US
Anwar Murtaza - Shrewsbury MA, US
Jochen Salfeld - North Grafton MA, US
Steven Fischkoff - Short Hills NJ, US

Assignee:

Abbott Laboratories S.A. - Baar

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

Methods for treating vasculitides in which TNF activity is detrimental are described.

US Patent:

20040136990, Jul 15, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/623035

Inventors:

Subhashis Banerjee - Shrewsbury MA, US
Lori Taylor - Wadsworth IL, US
Clive Spiegler - Reading, GB
Daniel Tracey - Harvard MA, US
Elliot Chartash - Randolph NJ, US
Rebecca Hoffman - Wilmette IL, US
William Barchuk - Madison NJ, US
Philip Yan - Vernon Hills IL, US
Anwar Murtaza - Westborough MA, US
Jochen Salfeld - North Grafton NC, US
Steven Fischkoff - Short Hills NJ, US

Assignee:

Abbott Biotechnology Ltd. - Hamilton

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

Methods for treating pain syndromes in which TNF activity is detrimental are described.