Darcy B Wilson

US Patent:

6464978, Oct 15, 2002

Filed:

Apr 29, 1993

Appl. No.:

08/055006

Inventors:

Steven W. Brostoff - Carlsbad CA
Darcy B. Wilson - La Jolla CA
Lawrence R. Smith - Cardiff CA
Daniel P. Gold - Del Mar CA
Dennis J. Carlo - Rancho Santa Fe CA

Assignee:

The Immune Response Corporation - Carlsbad CA

International Classification:

A61K 39395

US Classification:

4241541, 4241841, 4241851, 4241831, 530300, 530350, 5303879, 5303896, 5303913, 5303917, 435 6, 435 71

Abstract:

The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. The vaccine is administered to the mammal in a manner that induces an immunologically effective response so as to affect the course of the disease. The invention additionally provides specific -chain variable regions of the T cell receptor, designated V6. 2/3, V6. 5, V2, V5. 1, V13 and V7, which are central to the pathogenesis of multiple sclerosis (MS).

US Patent:

56987676, Dec 16, 1997

Filed:

Oct 16, 1995

Appl. No.:

8/543449

Inventors:

Darcy B. Wilson - La Jolla CA
Donald E. Mosier - Del Mar CA

Assignee:

Lidak Pharmaceuticals - La Jolla CA

International Classification:

A61K 3500
A61K 4800
C12N 1500

US Classification:

800 2

Abstract:

Laboratory non-human animals in which the immune system of a donor is induced in and thrives in vivo and expresses the immune response of the donor animal in a recipient non-human animal of a different species than the donor, and wherein malignant immune system cells of the donor can be induced in the recipient non-human animal by injection of non-malignant donor into the recipient are disclosed.

US Patent:

54769965, Dec 19, 1995

Filed:

May 4, 1993

Appl. No.:

8/057006

Inventors:

Darcy B. Wilson - La Jolla CA
Donald E. Mosier - Del Mar CA

Assignee:

Lidak Pharmaceuticals - La Jolla CA

International Classification:

A61K 3500

US Classification:

800 2

Abstract:

Laboratory non-human animals in which the immune system of a human donor is induced in and thrives in vivo and expresses the immune response of the human donor in a recipient non-human animal, and wherein malignant immune system cells of the human donor can be induced in the recipient non-human animal by injection of non-malignant donor cells into the recipient are disclosed.