Darrell Leigh Fisher

US Patent:

6869588, Mar 22, 2005

Filed:

May 9, 2001

Appl. No.:

09/853507

Inventors:

Richard E. Weller - Selah WA, US
Michael A. Lind - Kent WA, US
Darrell R. Fisher - Richland WA, US
Anna Gutowska - Richland WA, US
Allison A. Campbell - Kennewick WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K051/00
A61M036/14

US Classification:

424 129, 424 111, 424 137

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

US Patent:

20040228794, Nov 18, 2004

Filed:

Feb 19, 2004

Appl. No.:

10/784147

Inventors:

Richard Weller - Selah WA, US
Darrell Fisher - Richland WA, US
Michael Lind - Kent WA, US
Allison Campbell - Kennewick WA, US
Anna Gutowska - Richland WA, US
Craig Habeger - Chillicothe IL, US

Assignee:

Battelle Memorial Institute

International Classification:

A61K051/00
A61K033/42

US Classification:

424/001110, 424/604000

Abstract:

Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed. For example, the carrier compositions can be injected into a tumor to treat a cancer and can be applied to the margins of a resected tumor to destroy vestigal cancer cells.

US Patent:

62968319, Oct 2, 2001

Filed:

Apr 10, 1998

Appl. No.:

9/058712

Inventors:

Richard E. Weller - Selah WA
Michael A. Lind - Kent WA
Darrell R. Fisher - Richland WA
Anna Gutowska - Richland WA
Allison A. Campbell - Kennewick WA

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K 5100
A61M 3614

US Classification:

424 129

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.