David L Amrani

US Patent:

6461325, Oct 8, 2002

Filed:

Aug 31, 1999

Appl. No.:

09/386198

Inventors:

Yves Delmotte - Tertre, BE
Arnold Bilstad - Deerfield IL
David Amrani - Glendale WI
James DiOrio - Antioch IL
Atif M. Yardimci - Northbrook IL
David W. Pennington - Fox Lake IL
James S. Slepicka - Spring Grove IL
Cristina Stadler - Evanston IL

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 3700

US Classification:

604 82, 604191

Abstract:

This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.

US Patent:

6835186, Dec 28, 2004

Filed:

Sep 26, 2000

Appl. No.:

09/669353

Inventors:

David W. Pennington - Fox Lake IL
Atif M. Yardimci - Northbrook IL
David Amrani - Glendale WI
Arnold C. Bilstad - Deerfield IL
Yves A. Delmotte - Neufmaison, BE
James P. Diorio - Antioch IL
Robert L. Petersen - Winthrop Harbor IL
Joseph F. Prybell - Grayslake IL
James Slepicka - Spring Grove IL
Cristina Stadler - Columbus IN
John Womelsdorf - Caldwell NJ

Assignee:

Baxter International, Inc. - Deerfield IL

International Classification:

A61M 3700

US Classification:

604 82

Abstract:

This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid in which separate MBUs atomize the fluids. The device of the present invention includes a fluid delivery device for laparoscopically delivering fluids having two feed conduits for delivering fluid to feed ports of the mechanical breakup units, the mechanical breakup units having two feed ports for receiving fluid from the feed conduits and directing such fluid into spin chambers and funneling portions having a sloped sidewall for directing fluid from the spin chambers through an exit port. The device is suitably dimensioned for creating a spray of two fluids with different viscosities such as fibrinogen and thrombin in such a manner that the thrombin spray cone encompasses the fibrinogen spray cone at a distance of about one inch from the exit port with a 0. 5 cc/second flow rate to avoid depositing unreacted fibrinogen on a surface. Other instruments such as optical fibers may be incorporated within the device.

US Patent:

20100028311, Feb 4, 2010

Filed:

Jul 9, 2009

Appl. No.:

12/500582

Inventors:

Delara Motlagh - Barrington IL, US
David L. Amrani - Glendale WI, US
James P. Diorio - Antioch IL, US

Assignee:

BAXTER INTERNATIONAL INC. - Deerfield IL
BAXTER HEALTHCARE S.A. - Glattpark (Opfikon)

International Classification:

A61K 35/12
A61P 9/10

US Classification:

424 937

Abstract:

The invention generally relates to the field of delivery of cells to desired tissue sites, prolonged retention of the cells at the sites, and integration of cells into an area of interest for increased therapeutic effect. The invention provides, in part, compositions and methods for treating ischemia in a subject in need thereof. In some aspects, the methods of treatment comprise the administration of a fibrin scaffold or fibrin clot comprising stem cells.

US Patent:

20110091427, Apr 21, 2011

Filed:

Sep 30, 2010

Appl. No.:

12/894303

Inventors:

David L. Amrani - Glendale WI, US
Delara Motlagh - Barrington IL, US
Catherine M. Hoff - Lake Bluff IL, US
Amy Cohen - Grayslake IL, US
Jeremy Duffield - Seattle WA, US

Assignee:

BAXTER INTERNATIONAL INC. - Deerfield IL
BAXTER HEALTHCARE S.A. - Glattpark (Opfikon)

International Classification:

A61K 35/12
A61K 35/28

US Classification:

424 937

Abstract:

Provided herein are methods of treating a kidney injury in a patient, comprising administering to the patient hematopoietic stem cells (HSCs) in an amount effective to treat the kidney injury. In some embodiments, administration of the HSCs is delayed, such that the HSCs are not administered immediately after the kidney injury. In certain aspects, the HSCs are administered to the patient during the beginning of the repair phase of the kidney. Further embodiments and aspects of the invention, including related methods and compositions for use therein, are described herein.

US Patent:

20110274667, Nov 10, 2011

Filed:

Oct 19, 2009

Appl. No.:

13/124632

Inventors:

Anthony Donofrio - Westmont IL, US
Delara Motlagh - Barrington IL, US
David L. Amrani - Glendale WI, US
Amy Cohen - Grayslake IL, US

Assignee:

Baxter Healthcare S.A. - Glattpark (Opfikon)
Baxter International Inc. - Deerfield

International Classification:

A61K 35/12
A61P 9/10
A61P 13/12
A61P 37/06
A61P 27/02
A61P 17/02
C12N 5/077
A61P 3/10

US Classification:

424 937, 435325

Abstract:

Provided herein are methods of efficiently obtaining large numbers of viable, freshly isolated cells from small amounts of adipose tissue, as well as methods of enriching or selecting for target cell populations found therein. In certain embodiments, the method of obtaining a population of cells from adipose tissue comprises incubating the adipose tissue in a solution comprising an enzyme at a concentration which is at least 200 U/ml solution and not more than about 319 U/ml solution. In some embodiments, the method is devoid of any steps which expand the population of cells obtained. In certain aspects, the method further comprises positive or negative selection steps for obtaining an enriched population of target cells from adipose tissue. Related methods of preparing a pharmaceutical composition comprising cells for administration to a patient and methods of treating a disease or medical condition in a patient are further provided herein.

US Patent:

20130216495, Aug 22, 2013

Filed:

Feb 21, 2013

Appl. No.:

13/773390

Inventors:

BAXTER INTERNATIONAL INC. - , US
BAXTER HEALTHCARE SA - , US
Lora Palmer - Algonquin IL, US
David L. Amrani - Glendale WI, US

Assignee:

BAXTER HEALTHCARE SA - Glattpark (Opfikon)
BAXTER INTERNATIONAL INC. - Deerfield IL

International Classification:

A61K 35/14
A61K 35/12

US Classification:

424 851, 424 937

Abstract:

The invention relates to the field of treatment of ischemic conditions and diseases using a cell population comprising CD34+ cells isolated from peripheral blood of a subject. The invention provides a pharmaceutical composition comprising (i) a cell population comprising CD34+ cells, (ii) a plasma protein, and (iii) an isotonic solution comprising at least one salt, said isotonic solution comprising acetate, gluconate, or both acetate and gluconate. Methods of treating tissue damaged by ischemia in a subject and methods of treating a medical condition, wherein the pharmaceutical composition of the invention is administered, are further provided herein. Also, methods of promoting mobilization of CD34+ cells from bone marrow into peripheral blood are provided herein.

US Patent:

59892153, Nov 23, 1999

Filed:

Jul 12, 1996

Appl. No.:

8/679658

Inventors:

Yves Delmotte - Tertre, BE
Arnold Bilstad - Deerfield IL
David Amrani - Glendale WI
Mark Kennedy - Crystal Lake IL
James DiOrio - Antioch IL

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 3700

US Classification:

604 82

Abstract:

This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.

US Patent:

59029374, May 11, 1999

Filed:

Oct 1, 1997

Appl. No.:

8/941994

Inventors:

David L. Amrani - Glendale WI
Danial R. Boggs - Libertyville IL
Keith A. Earles - Waukegan IL

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

G01N3/02;37/00

US Classification:

73856

Abstract:

An in vitro tissue testing system especially useful for testing blood/tissue interactions. The system includes a tissue holding frame which forms a chamber between two flat pieces of tissue with a spacer plate therebetween. The spacer plate includes a reservoir aperture bordered on both sides by the opposed tissue pieces, and a mechanism for depressing portions of the tissue pieces inwardly into the chamber to propel blood from one side of the chamber to the other. The flow created simulates actual blood flow in a host system. The reservoir aperture may be hourglass shaped with circular end portions and a middle blood passageway. The actuating mechanism may include pistons for alternating contact with the tissue within the confines of the opposite reservoir end portions, thus propelling blood from one end portion to the other. The pistons may be driven by a plurality of eccentric cams on shafts coupled to a common drive motor. The holding frame may include two outer plates for sandwiching the tissue pieces against the spacer plate, the outer pieces having openings corresponding to the reservoir end portions, and the pistons reciprocate through the openings into contact with the tissue.