David A Andrews

US Patent:

6541036, Apr 1, 2003

Filed:

Aug 13, 1999

Appl. No.:

09/374712

Inventors:

David W. Andrews - Philadelphia PA
Renato L. Baserga - Ardmore PA
Mariana Resnicoff - Buenos Aires, AR
David Abraham - Wynnewood PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3512

US Classification:

424573, 424572, 424422, 424424, 424 931, 536 231, 514 44, 4353201, 435325

Abstract:

A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a human for a therapeutically effective time, thereby inducing resistance to or regression of tumor growth.

US Patent:

58107606, Sep 22, 1998

Filed:

Aug 8, 1996

Appl. No.:

8/694105

Inventors:

David W. Andrews - Philadelphia PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61M 500

US Classification:

604 8

Abstract:

Catheters for removing interstitial fluid from a cerebral edema that comprises an edema drainage section terminating in a proximal tip linked to a fluid transport section terminating in a distal tip are disclosed. The edema drainage section comprises an outer wall, an inner drainage tube and an intermediate solute compartment that comprises a solute. Methods of removing fluid from a cerebral edema of an individual are disclosed, and comprise the steps of inserting the edema drainage section of the catheter into communication with the fluid of the cerebral edema and inserting the fluid transport section of the catheter into a fluid receptacle or the individual's peritoneal cavity. The fluid is drawn into the edema drainage section and emerges from the distal tip of the fluid transport section of the catheter.

US Patent:

60960191, Aug 1, 2000

Filed:

Sep 22, 1998

Appl. No.:

9/158245

Inventors:

David W. Andrews - Philadelphia PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61M 3100

US Classification:

604500

Abstract:

Catheters for removing interstitial fluid from a cerebral edema that comprises an edema drainage section terminating in a proximal tip linked to a fluid transport section terminating in a distal tip are disclosed. The edema drainage section comprises an outer wall, an inner drainage tube and an intermediate solute compartment that comprises a solute. Methods of removing fluid from a cerebral edema of an individual are disclosed, and comprise the steps of inserting the edema drainage section of the catheter into communication with the fluid of the cerebral edema and inserting the fluid transport section of the catheter into a fluid receptacle or the individual's peritoneal cavity. The fluid is drawn into the edema drainage section and emerges from the distal tip of the fluid transport section of the catheter.

US Patent:

20210403918, Dec 30, 2021

Filed:

Oct 31, 2019

Appl. No.:

17/290797

Inventors:

- Philadelphia PA, US
David Andrews - Philadelphia PA, US
Emily Bongiorno - Philadelphia PA, US

International Classification:

C12N 15/113
C12N 5/09
A61K 35/13
A61K 39/00
A61P 35/00
C12N 11/00

Abstract:

The present disclosure relates to compositions and methods for treating liver cancers, especially hepatocellular carcinoma, using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of liver cancer.

US Patent:

20200038429, Feb 6, 2020

Filed:

Apr 19, 2018

Appl. No.:

16/606377

Inventors:

- Bellaire TX, US
- Philadephia PA, US
David W. Andrews - Philadelphia PA, US

Assignee:

Bio-Path Holdings, Inc. - Bellaire TX
Thomas Jefferson University - Philadephia PA

International Classification:

A61K 31/7125
A61K 47/69
A61P 35/00

Abstract:

Provided herein are methods of treating cancer or an autoimmune disease comprising administering a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide that targets a IGF-1R-encoding polynucleotide.