David E Baskin

Address:

12006 Barrycliff Ct, Houston, TX 77070

Phone:

(281)7972151

VIN:

1GCEK19007Z560681

Make:

CHEVROLET

Model:

SILVERADO 1500

Year:

2007

US Patent:

6864058, Mar 8, 2005

Filed:

Feb 6, 2002

Appl. No.:

10/068065

Inventors:

Vladimir Didenko - Houston TX, US
David Baskin - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12Q001/68
G01N001/30
G01N033/48
C07H021/02
C07H021/04

US Classification:

435 6, 435 405, 536 231, 536 243

Abstract:

Several types of DNA cuts are used as markers of apoptosis for detection of apoptotic cells in situ. The present invention includes a method to detect DNase II type DNA damage, bearing 5′OH using vaccinia topoisomerase I. The present invention also includes a method combining a ligase-based method to detect DNase I type DNA damage and the topoisomerase based method, resulting in simultaneous detection of two specific types of DNA damage in situ.

US Patent:

20130157261, Jun 20, 2013

Filed:

Jun 1, 2012

Appl. No.:

13/487058

Inventors:

Martyn Alun Sharpe - Houston TX, US
David S. Baskin - Houston TX, US

Assignee:

The Methodist Hospital Research Institute - Houston TX

International Classification:

G01N 21/64
G01N 33/53
C12Q 1/68

US Classification:

435 61, 530354, 435188, 435 71, 4352831

Abstract:

Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample.

US Patent:

48596744, Aug 22, 1989

Filed:

Aug 3, 1988

Appl. No.:

7/228827

Inventors:

David Baskin - Houston TX
Dominic M. K. Lam - The Woodlands TX

Assignee:

Houston Biotechnology Incorporated - The Woodlands TX

International Classification:

A61K 31495

US Classification:

514255

Abstract:

Neurologic dysfunction resulting from stroke is diminished by administering to a patient an effective amount of a tetra-substituted pyrazine over a relatively continuous regimen. Conveniently, an initial bolus is administered to bring the level of the drug up to a pre-determined blood level, followed by continuous infusion employing a pump or by continuous intravenous infusion.

US Patent:

20220193436, Jun 23, 2022

Filed:

Dec 31, 2021

Appl. No.:

17/567101

Inventors:

- Houston TX, US
David Stuart Baskin - Houston TX, US
Martyn Alun Sharpe - Houston TX, US
Kumar Pichumani - Sugar Land TX, US

International Classification:

A61N 2/00
A61N 2/06
A61N 2/12

Abstract:

The disclosure provides methods of cancer treatment and apparatus and, more particularly, to non-invasive cancer treatments utilizing oscillating magnetic fields to disrupt mitochondrial function or induce apoptosis or another mechanism of cell death in cancer cells. The disclosure also provides a device for providing an OMF treatment to a subject.

US Patent:

20210402199, Dec 30, 2021

Filed:

Nov 13, 2019

Appl. No.:

17/293461

Inventors:

- Houston TX, US
David Stuart Baskin - Houston TX, US
Martyn Alun Sharpe - Houston TX, US
Kumar Pichumani - Sugar Land TX, US

International Classification:

A61N 2/00
A61K 31/19
A61K 31/20
A61N 2/12

Abstract:

To disrupt mitochondrial function in certain cells, controlling hardware causes a magnet to oscillate so as to generate an oscillating magnetic field. The oscillating magnetic field is applied to a volume of tissue including cells with degraded mitochondria to trigger apoptosis in the cells with degraded mitochondria.

US Patent:

20140154269, Jun 5, 2014

Filed:

Apr 26, 2012

Appl. No.:

14/114051

Inventors:

James M. Tour - Bellaire TX, US
Jacob Berlin - Monrovia CA, US
Daniela Marcano - Houston TX, US
David S. Baskin - Houston TX, US
Martyn A. Sharpe - Houston TX, US

Assignee:

The Methodist Hospital Research Institute - Houston TX
William Marsh Rice University - Houston TX

International Classification:

A61K 9/00

US Classification:

4241741, 514 44 A, 514 44 R, 424649, 514 193

Abstract:

In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.