David Owen Baumann

US Patent:

20200109173, Apr 9, 2020

Filed:

Oct 9, 2019

Appl. No.:

16/596992

Inventors:

- Los Alamos NM, US
David Owen Baumann - Los Alamos NM, US
John Cameron Gordon - Los Alamos NM, US

Assignee:

Triad National Security, LLC - Los Alamos NM

International Classification:

C07K 7/54
A61K 47/64

Abstract:

The present disclosure provides peptoid-based chelating ligands, corresponding cyclic peptoids, and methods of making thereof. Functional groups may be tailored for high metal binding affinity and selectivity. The side chains of a cyclic peptoid according to the present disclosure may be selected based on, for example, high affinity for actinide or other metal ions, selectivity for actinide or other metal ions, the ability to recover a metal once it is bound to the peptoid, and whether the overall peptoid should be hydrophobic or hydrophilic. Unlike siderophores, peptoid-based chelating ligands of the present disclosure are not readily hydrolyzed under physiological conditions. Therefore, peptoid-based chelating ligands may be, for example, used to treat actinide (e.g., iron and lead) poisoning in vivo. Moreover, peptoid-based chelating ligands of the present disclosure may be used for medical imaging, chelation therapy, drug delivery, and separation technologies, for example.