David C Beach

US Patent:

6495526, Dec 17, 2002

Filed:

Jul 29, 1997

Appl. No.:

08/902572

Inventors:

Jeno Gyuris - Winchester MA
Lou Lamphere - Boston MA
David H. Beach - Huntington Bay NY

Assignee:

GPC Biotech, Inc. - Waltham MA

International Classification:

A61K 4800

US Classification:

514 44, 536 234, 536 2372, 536 241

Abstract:

The present invention pertains to novel inhibitors of cyclin-dependent kinases (CDKs), particularly CDK/cyclin complexes, which inhibitors can be used to control proliferation and/or differentiation of cells in which the inhibitors are introduced.

US Patent:

56725086, Sep 30, 1997

Filed:

Jan 23, 1996

Appl. No.:

8/589981

Inventors:

Jeno Gyuris - Winchester MA
Lou Lamphere - Boston MA
David Beach - Huntington Bay NY

Assignee:

Mitotix, Inc. - Cambridge MA

International Classification:

C12N 1562
C07H 2104

US Classification:

4353201

Abstract:

The present invention pertains to novel inhibitors of cyclin-dependent kinases (CDKs), particularly CDK/cyclin complexes, which inhibitors can be used to control proliferation and/or differentiation of cells in which the inhibitors are introduced. More specifically, the inhibitors of the invention are chimeric proteins which include CDK-binding motifs from two or more different proteins. For example, the subject chimeric proteins can be generated from the in-frame fusion of coding sequences from two different CDK inhibitor proteins, such as may be derived from fusion of coding sequences for an INK4 protein and coding sequences for a CIP protein. Chimeric proteins of the present invention have been observed to be more potent inhibitors of cyclin/CDK complexes than were either of the portions of the chimeric protein individually.

US Patent:

20220320769, Oct 6, 2022

Filed:

Apr 1, 2021

Appl. No.:

17/220454

Inventors:

- Sycamore IL, US
Richard Scott Horner - Marlborough MA, US
David Scott Beach - Oxford MA, US
Daniel Keith Gruenemeier - Scottsdale AZ, US

International Classification:

H01R 12/71
H01R 13/621
H01R 13/627

Abstract:

An electrical connector includes a universal plug body, a plurality of electrical contacts disposed in the universal plug body, and a printed circuit board (PCB), coupled with the universal plug, comprising a plurality of electrically-conductive features configured to electrically connect the plurality of electrical contacts to a plurality of terminals. Different PCB types may be used with the universal plug body to accommodate different power and data applications with a universal connector body.